Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266003 China.
Institute of Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266003 China.
Ageing Res Rev. 2023 Sep;90:101993. doi: 10.1016/j.arr.2023.101993. Epub 2023 Jun 27.
Macrophages are crucial in the progression of atherosclerotic cardiovascular disease (ASCVD). In the atherosclerotic lesions, macrophages play a central role in maintaining inflammatory response, promoting plaque development, and facilitating thrombosis. Increasing studies indicate that metabolic reprogramming and immune response mediate macrophage functional changes in all stages of atherosclerosis. In this review article, we explain how metabolic changes in glycolysis, oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid synthesis, fatty acid oxidation, and cholesterol metabolism regulate macrophage function in atherosclerosis. We discuss how immune response to oxidized lipids regulate macrophage function in atherosclerosis. Additionally, we explore how abnormal metabolism leads to macrophage mitochondrial dysfunction in atherosclerosis.
巨噬细胞在动脉粥样硬化性心血管疾病（ASCVD）的进展中起着至关重要的作用。在动脉粥样硬化病变中，巨噬细胞在维持炎症反应、促进斑块发展和促进血栓形成方面发挥着核心作用。越来越多的研究表明，代谢重编程和免疫反应介导了巨噬细胞在动脉粥样硬化各个阶段的功能变化。在这篇综述文章中，我们解释了糖酵解、氧化磷酸化、三羧酸循环、脂肪酸合成、脂肪酸氧化和胆固醇代谢中的代谢变化如何调节巨噬细胞在动脉粥样硬化中的功能。我们讨论了氧化脂质对巨噬细胞功能的免疫反应如何调节动脉粥样硬化中的巨噬细胞功能。此外，我们还探讨了异常代谢如何导致动脉粥样硬化中巨噬细胞线粒体功能障碍。
