人中性粒细胞对阴道加德纳菌的吞噬与杀伤作用
Phagocytosis and killing of Gardnerella vaginalis by human neutrophils.
作者信息
Easmon C S, Clark L, Crane J P, Green R
出版信息
J Clin Pathol. 1985 Jul;38(7):747-9. doi: 10.1136/jcp.38.7.747.
Abstract
Gardnerella vaginalis was ingested and killed by neutrophils in the presence of normal human serum. Heat inactivation of the serum inhibited these processes. The opsonisation of some but not all G vaginalis strains was enhanced by immune rabbit serum. Immune serum did not, however, enhance intracellular killing. Blockade of the classical pathway of complement activation had no effect on the opsonic activity of human serum. These results suggest that the opsonisation, phagocytosis, and killing of G vaginalis by human serum and neutrophils is primarily mediated by complement activated by the alternative pathway. Serum without neutrophils has little effect on the viability of G vaginalis.
摘要
在正常人血清存在的情况下，阴道加德纳菌被中性粒细胞摄取并杀死。血清热灭活会抑制这些过程。一些（但并非全部）阴道加德纳菌菌株的调理作用可被免疫兔血清增强。然而，免疫血清并未增强细胞内杀伤作用。阻断补体激活的经典途径对人血清的调理活性没有影响。这些结果表明，人血清和中性粒细胞对阴道加德纳菌的调理、吞噬和杀伤主要是由替代途径激活的补体介导的。不含中性粒细胞的血清对阴道加德纳菌的活力影响很小。
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