Eschenbach D A, Gravett M G, Chen K C, Hoyme U B, Holmes K K
Scand J Urol Nephrol Suppl. 1984;86:213-22.
Although bacterial vaginosis (BV) is a common disorder associated with high concentrations of potentially pathogenic micro-organisms, BV has not yet been linked to infections outside the vagina. To investigate the association of BV with adverse outcomes during or following pregnancy, we analysed the prevalence of BV among women with and without premature labor, and early-onset postpartum endometritis. Bacterial vaginosis was identified by gas-liquid chromatographic criteria in 28 (49%) of 57 women giving birth at less than or equal to 37 weeks gestation or with birthweight less than 2500 g and in 27 (24%) of 114 women bearing an infant at term (p = 0.001). Organisms associated with BV, such as Gardnerella vaginalis, anaerobic bacteria, and/or genital mycoplasmas, were recovered from the endometrium of 61 of 101 women with clinical signs of endometritis. G. vaginalis was the most frequent isolate from both the endometrium (38 patients) and the blood (8 patients) of women with postpartum endometritis. Bacteroides bivius was the most frequent anaerobic isolate from the endometrium (11 cases) and blood (4 cases). Patients with both G. vaginalis and anaerobes isolated remained febrile significantly longer after beginning antibiotic therapy than did other patients (57.1 hours. vs. 36.3 hours, p = 0.02). These data suggest that BV may be associated with prematurity and that BV may contribute to postpartum maternal infectious morbidity.
尽管细菌性阴道病（BV）是一种常见疾病，与高浓度潜在致病微生物相关，但BV尚未与阴道外感染相关联。为了研究BV与妊娠期间或产后不良结局之间的关联，我们分析了早产和早发型产后子宫内膜炎女性与未患这些疾病女性中BV的患病率。在妊娠小于或等于37周分娩或出生体重小于2500g的57名女性中，有28名（49%）根据气液色谱标准被诊断为细菌性阴道病；在足月分娩的114名女性中，有27名（24%）被诊断为此病（p = 0.001）。从101名有子宫内膜炎临床症状的女性的子宫内膜中分离出与BV相关的微生物，如阴道加德纳菌、厌氧菌和/或生殖支原体。阴道加德纳菌是产后子宫内膜炎女性子宫内膜（38例患者）和血液（8例患者）中最常分离出的菌株。双栖拟杆菌是子宫内膜（11例）和血液（4例）中最常分离出的厌氧菌。同时分离出阴道加德纳菌和厌氧菌的患者在开始抗生素治疗后发热时间明显长于其他患者（57.1小时对36.3小时，p = 0.02）。这些数据表明，BV可能与早产有关，并且BV可能导致产后母亲感染性发病。
