Ghafouri-Fard Soudeh, Gholami Leila, Badrlou Elham, Sadeghpour Saba, Nazer Naghme, Shadnoush Mahdi, Khalilian Sheyda, Sayad Arezou
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Periodontics, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Mol Cell Med. 2023;12(3):300-309. doi: 10.22088/IJMCM.BUMS.12.3.300.
Periodontitis is a chronic inflammatory condition affecting a large population all over the world. This condition is linked with abnormal expression of numerous genes. We measured levels of , , , and in gingival tissue and circulation of people with periodontitis and healthy controls. was more expressed in tissue samples of female patients compared with female controls (Ratio of mean expression (RME) =4.16, P=0.02). However, this gene was less expressed in the blood of female patients compared with female control subjects (RME=0.12, P=0.04). was less expressed in the blood of male patients compared with male controls (RME=0.20, P=0.02). Finally, was less expressed in total blood samples compared with total controls (RME=0.3, P<0.001) and in blood samples of female patients compared with female control subjects (RME=0.02, P<0.001). had the best area under curve (AUC) value in differentiation of patients' tissues from normal tissues (AUC=0.60, sensitivity=0.37, specificity=0.92). In distinction of abnormal blood samples from controls, had the best performance (AUC=0.85, sensitivity=0.66, specificity=0.91). In brief, we demonstrated a sex-dependent dysregulation of and genes in circulation or tissue of patients with periodontitis.
牙周炎是一种影响全球大量人口的慢性炎症性疾病。这种疾病与众多基因的异常表达有关。我们测量了牙周炎患者和健康对照者牙龈组织及血液循环中[此处基因名称缺失]、[此处基因名称缺失]、[此处基因名称缺失]、[此处基因名称缺失]和[此处基因名称缺失]的水平。与女性对照相比，[此处基因名称缺失]在女性患者的组织样本中表达更高（平均表达比值（RME）=4.16，P = 0.02）。然而，与女性对照受试者相比，该基因在女性患者血液中的表达较低（RME = 0.12，P = 0.04）。与男性对照相比，[此处基因名称缺失]在男性患者血液中的表达较低（RME = 0.20，P = 0.02）。最后，与总对照相比，[此处基因名称缺失]在全血样本中的表达较低（RME = 0.3，P < 0.001），与女性对照受试者相比，在女性患者血液样本中的表达也较低（RME = 0.02，P < 0.001）。[此处基因名称缺失]在区分患者组织与正常组织方面具有最佳的曲线下面积（AUC）值（AUC = 0.60，敏感性 = 0.37，特异性 = 0.92）。在区分异常血液样本与对照方面，[此处基因名称缺失]表现最佳（AUC = 0.85，敏感性 = 0.66，特异性 = 0.91）。简而言之，我们证明了牙周炎患者循环或组织中[此处基因名称缺失]和[此处基因名称缺失]基因存在性别依赖性失调。
