Illeni M T, Pasquali M, La Monica G, Böhm S, Rovini D, Di Re E
Eur J Gynaecol Oncol. 1985;6(2):121-5.
Sixty five patients affected by ovarian carcinoma, 40 controls with benign ovarian disease were typed for HLA A, B and C antigens and compared with 132 adult female blood donors. A highly significant increase in HLA B7 antigen (p = 0,0083) and a decrease in HLA A11, A28, B12 (p = 0,04; p = 0.03 respectively) in patients vs controls has been noticed. The comparison among the ovarian benign disease patients, and those with ovarian carcinoma and the healthy controls showed a decrease in the HLA A1 antigen frequency. Besides, the patients presented an increased and a decreased frequency of the A and O blood phenotypes respectively. These data confirm those of other Authors, and we can conclude that the neoplastic disease does not show a strong association with histocompatibility antigens.
对65例卵巢癌患者、40例患有良性卵巢疾病的对照者进行了HLA A、B和C抗原分型，并与132名成年女性献血者进行了比较。结果发现，与对照组相比，患者中HLA B7抗原显著增加（p = 0.0083），而HLA A11、A28、B12则减少（分别为p = 0.04；p = 0.03）。卵巢良性疾病患者、卵巢癌患者和健康对照者之间的比较显示，HLA A1抗原频率降低。此外，患者中A和O血型表型的频率分别增加和降低。这些数据证实了其他作者的数据，我们可以得出结论，肿瘤疾病与组织相容性抗原没有很强的关联。
