Hakami Aqilah A, Alorfi Hajar S, Farghaly Thoraya A, Hussein Mahmoud A
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Des Monomers Polym. 2024 May 15;27(1):1-20. doi: 10.1080/15685551.2024.2352897. eCollection 2024.
A new class of biologically active polyazomethine/pyrazole and their related nanocomposites, polyazomethine/pyrazole/zinc oxide nanoparticles, have been successfully synthesized through the polycondensation technique in the form of polyazomethine pyrazole (PAZm/Py) and polyazomethine/pyrazole/zinc oxide nanoparticles (PAZm/Py/ZnO). The polymeric nanocomposites were prepared with a 5% loading of zinc oxide nanofiller using the same preparation technique, in addition to the help of ultrasonic radiation. The characteristics of the new polymers, such as solubility, viscometry, and molecular weight, were examined. All the polymers were completely soluble in the following solvents: concentrated sulfuric acid, formic acid, dimethylformamide, dimethyl sulfoxide, and tetrahydrofuran. Furthermore, the weight loss of the polyazomethine pyrazole (4, 5, and 6) at 800 °C was 67%, 95%, and 86%, respectively, which indicates the thermal stability of these polymers. At 800 °C, the polyazomethine/pyrazole/zinc oxide nanoparticles (a, b, and c) lost 74%, 68%, and 75% of their weight, respectively. This shows that adding zinc oxide nanoparticles made these compounds more stable at high temperatures. The X-Ray diffraction pattern of the polyazomethine pyrazole (PAZm/Py) shows a number of sharp peaks with varying intensities. The polymers that were studied had straight crystal structures. Furthermore, the measurements of polyazomethine/pyrazole/zinc oxide nanoparticles (PAZm/Py/ZnO) indicate a good merging of zinc oxide nanoparticles into the matrix of polymers. The antimicrobial activity of polymers and polymer nanocomposites was tested against some selected bacteria and fungi. The synthesized polymer (c) shows the highest activity against the two types of gram-negative bacteria selected. Most tested compounds were found to be effective against gram-positive bacteria except polyazomethine pyrazole (PAZm/Py) and polyazomethine pyrazole (PAZm/Py), which do not exhibit any activity. The synthesized polymers and their related nanocomposites were tested for their ability to kill the chosen fungi. All of them were effective against Aspergillus flavus, but only polyazomethine pyrazole (PAZm/Py) and polyazomethine/pyrazole/zinc oxide (PAZm/Py/ZnO) were effective against Candida albicans.
一类新型生物活性聚甲亚胺/吡唑及其相关纳米复合材料，即聚甲亚胺/吡唑/氧化锌纳米颗粒，已通过缩聚技术成功合成，分别为聚甲亚胺吡唑（PAZm/Py）和聚甲亚胺/吡唑/氧化锌纳米颗粒（PAZm/Py/ZnO）。除了超声辐射的辅助外，还使用相同的制备技术制备了氧化锌纳米填料负载量为5%的聚合物纳米复合材料。对这些新型聚合物的特性，如溶解性、粘度和分子量进行了研究。所有聚合物都能完全溶解于以下溶剂：浓硫酸、甲酸、二甲基甲酰胺、二甲基亚砜和四氢呋喃。此外，聚甲亚胺吡唑（4、5和6）在800℃时的失重分别为67%、95%和86%，这表明这些聚合物具有热稳定性。在800℃时，聚甲亚胺/吡唑/氧化锌纳米颗粒（a、b和c）的失重分别为74%、68%和75%。这表明添加氧化锌纳米颗粒使这些化合物在高温下更稳定。聚甲亚胺吡唑（PAZm/Py）的X射线衍射图谱显示出许多强度不同的尖锐峰。所研究的聚合物具有直链晶体结构。此外，聚甲亚胺/吡唑/氧化锌纳米颗粒（PAZm/Py/ZnO）的测量结果表明氧化锌纳米颗粒很好地融入了聚合物基体。对聚合物和聚合物纳米复合材料对一些选定细菌和真菌的抗菌活性进行了测试。合成的聚合物（c）对所选的两种革兰氏阴性菌表现出最高活性。除聚甲亚胺吡唑（PAZm/Py）和聚甲亚胺吡唑（PAZm/Py）无任何活性外，大多数测试化合物对革兰氏阳性菌有效。对合成的聚合物及其相关纳米复合材料杀灭所选真菌的能力进行了测试。它们对黄曲霉均有效，但只有聚甲亚胺吡唑（PAZm/Py）和聚甲亚胺/吡唑/氧化锌（PAZm/Py/ZnO）对白色念珠菌有效。
