Xu Wenjiao, Yuan Guixin, Fang Yuwen, Liu Xiaojia, Ma Xiaowei, Zhu Kui
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Engineering Research Center of Animal Innovative Drugs and Safety Evaluation, Ministry of Education, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Research (Wash D C). 2024 May 16;7:0374. doi: 10.34133/research.0374. eCollection 2024.
Commensal enterococci with pathogenic potential often facilitate the growth of diverse pathogens, thereby exacerbating infections. However, there are few effective therapeutic strategies to prevent and intervene in enterococci-mediated polymicrobial infections. Here, we find that enterococci at high density drive the expansion and pathogenicity of enteric serotype Typhimurium (. Tm). Subsequently, we show that the driving role of enterococci in such infections is counteracted by dietary coumarin glycosides in vivo. Enterococci, which are tolerant of iron-deficient environments, produce β-glucosidases to hydrolyze coumarin glycosides into bioactive aglycones, inhibiting . Tm growth and ameliorating the severity of . Tm-induced symptoms by inducing iron limitation. Overall, we demonstrate that coumarin glycosides as a common diet effectively reverse enterococci-facilitated enteric infections, providing an alternative intervention to combat polymicrobial infections.
具有致病潜力的共生肠球菌通常会促进多种病原体的生长，从而加剧感染。然而，预防和干预肠球菌介导的多微生物感染的有效治疗策略很少。在这里，我们发现高密度的肠球菌会驱动肠道鼠伤寒血清型（. Tm）的扩张和致病性。随后，我们表明，体内的膳食香豆素糖苷可抵消肠球菌在这类感染中的驱动作用。耐缺铁环境的肠球菌会产生β-葡萄糖苷酶，将香豆素糖苷水解成具有生物活性的苷元，通过诱导铁限制来抑制. Tm的生长并减轻. Tm诱导症状的严重程度。总体而言，我们证明香豆素糖苷作为一种常见的饮食可有效逆转肠球菌促进的肠道感染，为对抗多微生物感染提供了一种替代干预措施。
