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癌症相关的胸主动脉动脉血栓形成:病例报告及文献综述

Cancer-associated thoracic aorta arterial thrombosis: case report and review of the literature.

作者信息

Borregón Miguel, Valero María, Ferrández Asia, Muñoz Álvaro, Roque Carmen, Benítez-Fuentes Javier-David

机构信息

Department of Medical Oncology, Hospital General Universitario de Elche, FISABIO, Alicante, Spain.

Department of Radiology, Hospital General Universitario de Elche, FISABIO, Alicante, Spain.

出版信息

Front Cardiovasc Med. 2025 Jan 29;12:1480310. doi: 10.3389/fcvm.2025.1480310. eCollection 2025.

Abstract

BACKGROUND

Arterial thrombosis is an uncommon complication in cancer patients, often overshadowed by venous thromboembolic events. Its occurrence in patients with solid tumors on active antineoplastic treatment poses a significant clinical challenge.

KEY CLINICAL QUESTION

Given the lack of consensus on the optimal therapy for arterial thrombosis in cancer patients, the best practices for managing an aortic thrombus, and the benefit of low molecular weight heparin (LMWH) must be reviewed.

CLINICAL APPROACH

We present the case of a 70-year-old female with stage IVA lung adenocarcinoma who developed an aortic thrombus during chemo-immunotherapy. The thrombus was successfully treated with LMWH, avoiding further complications, and allowing for the continuation of her cancer therapy.

CONCLUSIONS

This case highlights the importance of early detection and management of arterial thrombus in cancer patients. LMWH proved effective in resolving the thrombus, underscoring its role in managing such complications.

摘要

背景

动脉血栓形成在癌症患者中是一种不常见的并发症,常常被静脉血栓栓塞事件所掩盖。其在接受积极抗肿瘤治疗的实体瘤患者中的发生构成了重大的临床挑战。

关键临床问题

鉴于癌症患者动脉血栓形成的最佳治疗方法缺乏共识,必须重新审视管理主动脉血栓的最佳实践以及低分子量肝素(LMWH)的益处。

临床方法

我们介绍了一名70岁IV期肺腺癌女性患者的病例,该患者在化疗免疫治疗期间发生了主动脉血栓。该血栓通过低分子量肝素成功治疗,避免了进一步的并发症,并使其癌症治疗得以继续。

结论

该病例突出了癌症患者动脉血栓早期检测和管理的重要性。低分子量肝素在溶解血栓方面被证明是有效的,强调了其在管理此类并发症中的作用。

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