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初级保健中多领域痴呆风险降低是可行的:概念验证研究。

Multidomain Dementia Risk Reduction in Primary Care is Feasible: A Proof-of-concept study.

机构信息

Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, the Netherlands.

Department of Family Medicine, Careand Public Health Research Institute (CAPHRI), MaastrichtUniversity, Maastricht, the Netherlands.

出版信息

J Alzheimers Dis. 2024;99(4):1455-1471. doi: 10.3233/JAD-240229.

Abstract

BACKGROUND

Dementia risk reduction is a public health priority, but interventions that can be easily implemented in routine care are scarce.

OBJECTIVE

To evaluate the feasibility of integrating dementia risk reduction in regular consultations in primary care and the added value of a dedicated smartphone app ('MyBraincoach').

METHODS

188 participants (40-60 years), with modifiable dementia risk factors were included from ten Dutch general practices in a cluster-randomized trial (NL9773, 06/10/2021). Practices were randomly allocated (1 : 1) to provide a risk-reduction consultation only or to additionally provide the app. During the consultation, participants learned about dementia risk reduction and how to improve their risk profile. The app group received daily microteaching-notifications about their personally relevant risk factors. Feasibility was evaluated after 3 months using questionnaires assessing knowledge on dementia risk reduction and health behavior change. The primary outcome was change in the validated "LIfestyle for BRAin health" (LIBRA) score. In-depth interviews were conducted with participants and primary care providers (PCPs).

RESULTS

The interventions were positively perceived, with 72.0% finding the consultation informative and 69.2% considering the app useful. Drop-out was low (6.9%). LIBRA improved similarly in both groups, as did Mediterranean diet adherence and body mass index. Knowledge of dementia risk reduction increased, but more in the app group. Interviews provided insight in participants' and PCPs' needs and wishes.

CONCLUSIONS

Integrating dementia risk reduction in primary care, supported by a smartphone app, is a viable approach towards dementia risk reduction. Larger trials are needed to establish (cost-)effectiveness.

摘要

背景

降低痴呆风险是公共卫生的重点,但可在常规护理中实施的干预措施却很少。

目的

评估将痴呆风险降低纳入初级保健常规咨询的可行性,以及专用智能手机应用程序(“MyBraincoach”)的附加价值。

方法

从荷兰十家普通诊所招募了 188 名(40-60 岁)具有可改变的痴呆风险因素的参与者,他们参加了一项基于群组的随机试验(NL9773,2021 年 10 月 6 日)。这些诊所被随机分配(1:1)仅提供降低风险的咨询或另外提供应用程序。在咨询过程中,参与者了解了痴呆风险降低以及如何改善他们的风险状况。应用程序组每天会收到有关个人相关风险因素的微型教学通知。在 3 个月后使用评估痴呆风险降低和健康行为改变的知识的问卷来评估可行性。主要结果是经过验证的“生活方式对大脑健康(LIBRA)”评分的变化。对参与者和初级保健提供者(PCP)进行了深入访谈。

结果

干预措施受到积极评价,72.0%的参与者认为咨询内容丰富,69.2%的参与者认为应用程序有用。退出率很低(6.9%)。两组的 LIBRA 评分均有相似的改善,地中海饮食依从性和体重指数也有所改善。对痴呆风险降低的认识有所提高,但在应用程序组中更为明显。访谈提供了参与者和 PCP 的需求和愿望的见解。

结论

在初级保健中整合痴呆风险降低,辅以智能手机应用程序,是降低痴呆风险的可行方法。需要进行更大规模的试验来确定(成本)效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/11191460/a29148385989/jad-99-jad240229-g001.jpg

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