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Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development.

作者信息

Mobasheri Ali, Loeser Richard

机构信息

Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.

Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.

出版信息

Nat Rev Rheumatol. 2024 Sep;20(9):525-526. doi: 10.1038/s41584-024-01126-4.

DOI:10.1038/s41584-024-01126-4
PMID:38760581
Abstract
摘要

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本文引用的文献

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Prognostic value of B-score for predicting joint replacement in the context of osteoarthritis phenotypes: Data from the osteoarthritis initiative.骨关节炎表型背景下B评分对预测关节置换的预后价值：来自骨关节炎倡议的数据。
Osteoarthr Cartil Open. 2024 Mar 4;6(2):100458. doi: 10.1016/j.ocarto.2024.100458. eCollection 2024 Jun.
2
Machine Learning Approaches to the Prediction of Osteoarthritis Phenotypes and Outcomes.机器学习在预测骨关节炎表型和结局中的应用。
Curr Rheumatol Rep. 2023 Nov;25(11):213-225. doi: 10.1007/s11926-023-01114-9. Epub 2023 Aug 10.
3
Unsupervised machine-learning algorithms for the identification of clinical phenotypes in the osteoarthritis initiative database.
疾病修饰性骨关节炎药物研发中的新观念与挑战——更精准的视角
Arch Pharm Res. 2025 Jun 28. doi: 10.1007/s12272-025-01551-3.
4
Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype.重度骨关节炎患者的滑液细胞外囊泡差异性地促进分解代谢、炎症性软骨细胞表型。
Biomolecules. 2025 Jun 6;15(6):829. doi: 10.3390/biom15060829.
5
Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy.骨关节炎作为一种进化遗产：生物衰老与软骨细胞肥大。
Osteoarthr Cartil Open. 2025 May 13;7(3):100624. doi: 10.1016/j.ocarto.2025.100624. eCollection 2025 Sep.
6
Key Osteoarthritis Biomarkers: What Interventional Radiologists Performing Genicular Artery Embolization Need to Know.关键骨关节炎生物标志物：进行膝动脉栓塞术的介入放射科医生需要了解的内容。
Cardiovasc Intervent Radiol. 2025 May 21. doi: 10.1007/s00270-025-04045-3.
7
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research.超越症状匹配：评估骨关节炎研究中动物模型与人类病理类型匹配时因果机制的整合情况。
Arthritis Res Ther. 2025 May 17;27(1):109. doi: 10.1186/s13075-025-03561-4.
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Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: A 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections).在存在感染、肿瘤和血液系统合并症的情况下，富血小板血浆注射治疗肌肉骨骼疾病的适应症和禁忌症：来自GRIIP（国际血小板注射研究组）的2025年正式共识
Knee Surg Sports Traumatol Arthrosc. 2025 Jun;33(6):2293-2306. doi: 10.1002/ksa.12682. Epub 2025 Apr 22.
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Osteoarthr Imaging. 2025 Mar;5(1). doi: 10.1016/j.ostima.2024.100256. Epub 2024 Dec 25.
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Drug Des Devel Ther. 2021 Jul 6;15:2921-2945. doi: 10.2147/DDDT.S295224. eCollection 2021.
8
Emerging pharmaceutical therapies for osteoarthritis.骨关节炎的新兴药物疗法。
Nat Rev Rheumatol. 2020 Dec;16(12):673-688. doi: 10.1038/s41584-020-00518-6. Epub 2020 Oct 29.
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Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases.精准医学与过敏疾病的表型、内型、基因型、基因型、治疗型。
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Curr Opin Rheumatol. 2019 Jan;31(1):80-89. doi: 10.1097/BOR.0000000000000567.