早期类风湿关节炎中的骨转换。2. 纵向骨密度研究。
Bone turnover in early rheumatoid arthritis. 2. Longitudinal bone density studies.
作者信息
Sambrook P N, Ansell B M, Foster S, Gumpel J M, Hesp R, Reeve J
出版信息
Ann Rheum Dis. 1985 Sep;44(9):580-4. doi: 10.1136/ard.44.9.580.
Abstract
Serial measurements of bone mineral in 17 ambulant female patients with rheumatoid arthritis (RA) of recent onset and 19 age matched female controls were made in the radius by computed tomography and in the vertebrae by dual photon absorptiometry. Loss of trabecular bone from the distal radius was more rapid in RA (p = 0.0014), but there was no difference in the rate of loss of bone mineral from the radial midshaft or lumbar spine compared with the controls. This study is consistent with the hypothesis that the predominant form of bone loss early in the disease is the vicinity of affected joints.
摘要
对17例近期发病的活动期类风湿关节炎（RA）女性患者和19例年龄匹配的女性对照者进行了连续骨矿物质测量，采用计算机断层扫描测量桡骨，采用双能光子吸收法测量椎体。RA患者桡骨远端小梁骨丢失更快（p = 0.0014），但与对照组相比，桡骨中段或腰椎的骨矿物质丢失率没有差异。本研究与疾病早期主要的骨丢失形式是在受累关节附近这一假说相符。
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