Isenberg D A, Shoenfeld Y, Walport M, Mackworth-Young C, Dudeney C, Todd-Pokropek A, Brill S, Weinberger A, Pinkas J
Arthritis Rheum. 1985 Sep;28(9):999-1007. doi: 10.1002/art.1780280907.
Two common cross-reacting anti-DNA antibody idiotypes designated 16/6 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist among lupus relatives, as well as patients. These dominant or public anti-DNA antibody idiotypes are not likely to be pathogenic factors, but are probably a genetically associated phenomenon.
在系统性红斑狼疮患者血清中先前已鉴定出的两种常见的交叉反应性抗DNA抗体独特型，即16/6和32/15，在147名一级亲属中分别有24%和7%被发现。这些发现表明，狼疮患者及其亲属中存在高频种系基因。这些显性或常见的抗DNA抗体独特型不太可能是致病因素，而可能是一种遗传相关现象。
