Dudeney C, Shoenfeld Y, Rauch J, Jones M, Mackworth Young C, Tavassoli M, Shall S, Isenberg D A
Ann Rheum Dis. 1986 Jun;45(6):502-7. doi: 10.1136/ard.45.6.502.
The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross reacting anti-DNA antibody idiotype designated 134, antibodies to poly(ADP-ribose), serum C3, circulating immune complexes, and antinuclear antibodies (ANA). Over 30% of the relatives had raised 134 and anti-poly(ADP-ribose) levels, and 9% had ANA titres greater than 1/20. In contrast, only one relative had a low serum C3 level. These results confirm that immunogenetic abnormalities associated with the production of autoantibodies and particular idiotypes must exist amongst lupus relatives as well as the patients. The production of autoantibodies, however, is not necessarily matched to the clinical expression of SLE.
通过检测一种常见的、具有交叉反应性的抗DNA抗体独特型（命名为134）、抗聚（ADP - 核糖）抗体、血清C3、循环免疫复合物和抗核抗体（ANA），对31例狼疮患者和80例无症状的一级亲属的血清进行研究，重新审视了系统性红斑狼疮（SLE）的遗传背景。超过30%的亲属134和抗聚（ADP - 核糖）水平升高，9%的亲属ANA滴度大于1/20。相比之下，只有一名亲属血清C3水平较低。这些结果证实，与自身抗体和特定独特型产生相关的免疫遗传异常不仅存在于狼疮患者中，也存在于狼疮亲属中。然而，自身抗体的产生不一定与SLE的临床表现相匹配。
