Schiltknecht E, Ada G L
Cell Immunol. 1985 Oct 15;95(2):340-8. doi: 10.1016/0008-8749(85)90321-1.
Specific effector T cells that mediate DTH to influenza virus were found to be formed in vivo in CsA-treated mice. The activity of these cells could only be measured when they were transferred into untreated naive mice. The cells mediating DTH were H-2 restricted in the I region of the MHC. When effector T cells that mediated DTH were transferred into CsA-treated recipients, no DTH activity could be detected. Influenza-specific cytotoxic T cells could not be detected in the spleens of CsA-treated mice given virus intravenously, even when drug treatment was started 3 days after virus administration. There was only a partial restoration of cytotoxic activity when spleen cells from CsA-treated infected mice were cultured in the presence of virus-infected stimulators. This seemed to indicate that Class I-restricted responses were more susceptible to CsA than the generation of Class II (or I-region-restricted) responses.
发现介导对流感病毒迟发型超敏反应（DTH）的特异性效应T细胞在环孢素A（CsA）处理的小鼠体内形成。只有当这些细胞转移到未处理的幼稚小鼠体内时，才能检测到它们的活性。介导DTH的细胞在主要组织相容性复合体（MHC）的I区域受H-2限制。当介导DTH的效应T细胞转移到CsA处理的受体中时，无法检测到DTH活性。即使在静脉注射病毒3天后开始药物治疗，在静脉注射病毒的CsA处理小鼠的脾脏中也检测不到流感特异性细胞毒性T细胞。当来自CsA处理的感染小鼠的脾细胞在病毒感染的刺激物存在下培养时，细胞毒性活性只有部分恢复。这似乎表明I类限制的反应比II类（或I区域限制）反应的产生更容易受到CsA的影响。
