Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
Trends Parasitol. 2024 Jun;40(6):449-451. doi: 10.1016/j.pt.2024.05.002. Epub 2024 May 17.
Polymeric guanylate-binding proteins (GBPs) physically dismember the vacuole membrane formed by Toxoplasma gondii while nitric oxide (NO) poisons and inhibits parasite replication within interferon (IFN)-γ activated macrophages. Zhao et al. report a novel mechanism for synergy between these classical microbicidal and microbistatic effectors in cell-autonomous immunity to the intracellular parasites.
聚合鸟苷酸结合蛋白(GBPs)在物理上破坏了刚地弓形虫形成的空泡膜,而一氧化氮(NO)在干扰素(IFN)-γ激活的巨噬细胞内毒害和抑制寄生虫复制。Zhao 等人报道了这些经典杀菌和抑菌效应物在细胞自主免疫细胞内寄生虫中的协同作用的一种新机制。