Hai Erhan, Li Boyuan, Zhang Jian, Zhang Jiaxin
Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, Inner Mongolia, China.
Cell Death Discov. 2024 May 18;10(1):239. doi: 10.1038/s41420-024-02013-3.
Substantial progress in research on sperm cryopreservation has occurred since the twentieth century, especially focusing on improving sperm freezing procedures and optimizing semen extenders. However, the cellular biological mechanisms of sperm freezing damage are still unclear, which greatly restricts the promotion and development of sperm cryopreservation. An essential component of sperm freezing damage is the occurrence of cell death. Considering the existence of multiple types of cell death pathways, this review discusses connections between characteristics of regulated cell death (e.g., apoptosis and ferroptosis), and accidental cell death (e.g., intracellular ice crystals) with sperm freezing damage and explores possible future research directions in this field.
自20世纪以来，精子冷冻保存研究取得了重大进展，尤其侧重于改进精子冷冻程序和优化精液稀释液。然而，精子冷冻损伤的细胞生物学机制仍不清楚，这极大地限制了精子冷冻保存的推广和发展。精子冷冻损伤的一个重要组成部分是细胞死亡的发生。考虑到存在多种类型的细胞死亡途径，本文综述讨论了程序性细胞死亡（如凋亡和铁死亡）以及意外性细胞死亡（如细胞内冰晶形成）的特征与精子冷冻损伤之间的联系，并探索了该领域未来可能的研究方向。
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