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1
Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor.高分子量人B细胞生长因子的纯化至均一性；证明其与活化B细胞的特异性结合；以及针对该因子的单克隆抗体的研制。
J Exp Med. 1985 Oct 1;162(4):1319-35. doi: 10.1084/jem.162.4.1319.
2
Identification and characterization of a B cell growth inhibitory factor (BIF) on BCGF-dependent B cell proliferation.卡介苗生长因子依赖性B细胞增殖过程中一种B细胞生长抑制因子（BIF）的鉴定与特性分析
J Immunol. 1985 Jan;134(1):375-81.
3
Identification of a receptor for high molecular weight human B cell growth factor.高分子量人B细胞生长因子受体的鉴定
J Immunol. 1988 Aug 1;141(3):861-9.
4
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.一种可用于小鼠T细胞替代因子/B细胞生长因子II分子特征分析的单克隆抗体的制备。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4581-5. doi: 10.1073/pnas.84.13.4581.
5
Production of B cell growth factor by normal human B cells.正常人B细胞产生B细胞生长因子。
J Immunol. 1986 Jun 15;136(12):4542-7.
6
A mitogenic factor, released by stimulated human mononuclear cells and distinct from interleukin 2 (IL 2), B cell growth factor (BCGF), and interleukin 1 (IL 1).一种有丝分裂因子，由受刺激的人单核细胞释放，不同于白细胞介素2（IL-2）、B细胞生长因子（BCGF）和白细胞介素1（IL-1）。
J Immunol. 1984 Dec;133(6):3084-90.
7
B cell growth and differentiation factors interact with receptors distinct from the interleukin 2 receptor.B细胞生长和分化因子与不同于白细胞介素2受体的受体相互作用。
Eur J Immunol. 1986 Jul;16(7):761-6. doi: 10.1002/eji.1830160708.
8
Identification of a major 50-kDa molecular weight human B-cell growth factor with Tac antigen-inducing activity on B cells.鉴定一种主要的分子量为50 kDa的人B细胞生长因子，其对B细胞具有诱导Tac抗原的活性。
Cell Immunol. 1987 Aug;108(1):132-49. doi: 10.1016/0008-8749(87)90199-7.
9
A B cell growth factor-like activity is secreted by cloned, neoplastic B cells.克隆的肿瘤性B细胞分泌一种B细胞生长因子样活性物质。
J Immunol. 1984 Dec;133(6):3133-7.
10
Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia.慢性淋巴细胞白血病中白血病B细胞上人类高分子量B细胞生长因子受体的检测与特性分析
J Clin Invest. 1989 Nov;84(5):1595-608. doi: 10.1172/JCI114337.

引用本文的文献

1
Evaluation of chronic urticaria in patients with Hashimoto thyroiditis.桥本甲状腺炎患者慢性荨麻疹的评估
J Clin Immunol. 2001 Sep;21(5):335-47. doi: 10.1023/a:1012288602962.
2
A primer on cytokines: sources, receptors, effects, and inducers.细胞因子入门：来源、受体、作用及诱导剂
Clin Microbiol Rev. 1997 Oct;10(4):742-80. doi: 10.1128/CMR.10.4.742.
3
Identification of a cDNA for a human high-molecular-weight B-cell growth factor.人高分子量B细胞生长因子cDNA的鉴定。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6330-4. doi: 10.1073/pnas.90.13.6330.
4
T-24.B-cell differentiation factor induces immunoglobulin secretion in human B cells without prior cell replication.T-24.B细胞分化因子可在不进行细胞先复制的情况下诱导人B细胞分泌免疫球蛋白。
Immunology. 1987 Apr;60(4):523-9.
5
A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.一例人类B细胞白血病病例，提示自分泌机制与Leu 1 B细胞异常生长有关。
J Clin Invest. 1986 Nov;78(5):1331-8. doi: 10.1172/JCI112719.
6
Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.人B细胞的激活是通过两种不同的细胞表面分化抗原Bp35和Bp50介导的。
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4494-8. doi: 10.1073/pnas.83.12.4494.
7
B-cell stimulatory factors (BSFs): molecular structure, biological function, and regulation of expression.B细胞刺激因子（BSFs）：分子结构、生物学功能及表达调控
J Clin Immunol. 1987 Sep;7(5):343-55. doi: 10.1007/BF00917012.
8
Interleukin 4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin 2.白细胞介素4抑制活化的人B细胞对白介素2应答时的增殖，但不抑制其分化。
J Exp Med. 1988 Oct 1;168(4):1321-37. doi: 10.1084/jem.168.4.1321.
9
The Bb fragment of complement factor B acts as a B cell growth factor.补体因子B的Bb片段作为一种B细胞生长因子。
J Exp Med. 1988 Oct 1;168(4):1225-35. doi: 10.1084/jem.168.4.1225.
10
The marmoset B-lymphoblastoid cell line (B95-8) produces and responds to B-cell growth and differentiation factors: role of shed CD23 (sCD23).狨猴B淋巴细胞系（B95-8）产生并对B细胞生长和分化因子作出反应：可溶性CD23（sCD23）的作用。
Immunology. 1988 Nov;65(3):379-84.

本文引用的文献

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Radioiodination by use of the Bolton-Hunter and related reagents.使用博尔顿-亨特试剂及相关试剂进行放射性碘化。
Methods Enzymol. 1980;70(A):221-47. doi: 10.1016/s0076-6879(80)70052-6.
2
The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses.白细胞介素2在诱导细胞毒性T细胞和抗体形成B细胞反应中的生物化学、生物学及作用。
Immunol Rev. 1982;63:129-66. doi: 10.1111/j.1600-065x.1982.tb00414.x.
3
B cell growth factor and T cell growth factor produced by mitogen-stimulated normal human peripheral blood T lymphocytes are distinct molecules.有丝分裂原刺激的正常人外周血T淋巴细胞产生的B细胞生长因子和T细胞生长因子是不同的分子。
J Immunol. 1982 Dec;129(6):2486-9.
4
Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).正常人B淋巴细胞的增殖反应。人B细胞生长因子（BCGF）检测系统的建立。
J Immunol. 1982 Sep;129(3):1104-8.
5
T cell enrichment and depletion of human peripheral blood mononuclear cell preparations. Unexpected findings in the study of the functional activities of the separated populations.人外周血单个核细胞制剂的T细胞富集与去除。分离群体功能活性研究中的意外发现。
J Immunol Methods. 1982;50(1):39-49. doi: 10.1016/0022-1759(82)90302-7.
6
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
7
Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors.抗免疫球蛋白和T细胞因子对人B白血病细胞增殖及免疫球蛋白产生的诱导作用。
J Immunol. 1982 Mar;128(3):1296-301.
8
Immortalized B lymphocytes produce B-cell growth factor.永生化B淋巴细胞产生B细胞生长因子。
Nature. 1984;310(5973):145-7. doi: 10.1038/310145a0.
9
Development of a human T-cell hybridoma secreting separate B-cell growth and differentiation factors.分泌不同B细胞生长和分化因子的人T细胞杂交瘤的研制
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2475-8. doi: 10.1073/pnas.81.8.2475.
10
Partial purification and characterization of a BCGFII from EL4 culture supernatants.从EL4培养上清液中对一种白细胞介素-2的B细胞生长因子（BCGFII）进行部分纯化及特性鉴定。
J Immunol. 1984 May;132(5):2451-6.

高分子量人B细胞生长因子的纯化至均一性；证明其与活化B细胞的特异性结合；以及针对该因子的单克隆抗体的研制。

Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor.

作者信息

Ambrus J L, Jurgensen C H, Brown E J, Fauci A S

出版信息

J Exp Med. 1985 Oct 1;162(4):1319-35. doi: 10.1084/jem.162.4.1319.

DOI:10.1084/jem.162.4.1319
PMID:3876402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187866/
Abstract

High molecular weight B cell growth factor (HMW-BCGF) produced by a T cell line was purified to homogeneity and demonstrated to bind specifically to activated human B cells. A monoclonal antibody to HMW-BCGF was developed that (a) specifically inhibited the activity of HMW-BCGF in enhancing B cell proliferation, (b) specifically bound to HMW-BCGF in Western blots, (c) specifically absorbed HMW-BCGF activity from culture supernatants, and (d) specifically absorbed an internally labeled protein from T-ALL supernatant which comigrates with HMW-BCGF on sodium dodecyl sulfate-polyacrylamide gels. This antibody should help in cloning the gene for HMW-BCGF and further exploring the physiologic roles of HMW-BCGF.

摘要

一种T细胞系产生的高分子量B细胞生长因子（HMW-BCGF）被纯化至均一，并证明其能特异性结合活化的人B细胞。针对HMW-BCGF开发了一种单克隆抗体，该抗体：（a）能特异性抑制HMW-BCGF增强B细胞增殖的活性；（b）在蛋白质免疫印迹中能特异性结合HMW-BCGF；（c）能从培养上清液中特异性吸附HMW-BCGF的活性；（d）能从T-ALL上清液中特异性吸附一种在十二烷基硫酸钠-聚丙烯酰胺凝胶上与HMW-BCGF迁移率相同的内部标记蛋白。这种抗体应有助于克隆HMW-BCGF的基因，并进一步探索HMW-BCGF的生理作用。