Aljuboori Ismael W, Mahmood Maha S, Al-Rihaymee Sarah A
Department of Periodontics, College of Dentistry, Ashur University, Baghdad, IRQ.
Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, IRQ.
Cureus. 2024 Apr 19;16(4):e58582. doi: 10.7759/cureus.58582. eCollection 2024 Apr.
Background Periodontitis is a chronic inflammatory condition that destroys the tissues supporting the teeth. Conventional nonsurgical treatments, such as mechanical scaling and root surface debridement (RSD), often require adjunct therapies to enhance outcomes due to their limited efficacy in completely eradicating pathogenic microorganisms. Given the adverse effects of standard adjunctive therapies, including antibiotics and nonsteroidal anti-inflammatory drugs, (sage) presents a promising herbal alternative due to its anti-inflammatory and antimicrobial properties. This study aims to assess the local application of Salvia officinalis gel as an adjunctive to scaling and RSD to manage periodontitis. Methods We conducted a randomized, controlled split-mouth clinical trial involving 14 systemically healthy periodontitis patients. We included patients with at least 20 natural teeth, a probing pocket depth (PPD) ≥5 mm, and attachment loss ≥4 mm at a minimum of five sites. Primary outcomes measured were bleeding on probing (BOP), PPD, and relative attachment level (RAL). The gel was applied to designated test sites post-RSD, while control sites received no adjunctive treatment. Clinical parameters were recorded at baseline and a one-month follow-up visit. Results The cohort consisted of 10 men and four women, with a mean age of 37.1 ± 5.46 years. At the follow-up visit, the test group demonstrated a significant reduction in mean BOP (P = 0.0004), whereas the control group showed no significant change (P ≥ 0.05). Both groups experienced significant decreases in mean PPD and RAL from baseline to follow-up, with the test group showing greater improvements. Conclusions gel, used as an adjunct to scaling and RSD, significantly improves clinical periodontal parameters in patients with periodontitis. Its anti-inflammatory properties likely underpin the observed benefits, offering an effective and safe alternative to traditional chemical pharmaceuticals. Further research is needed to explore the long-term effects and mechanisms underlying the therapeutic benefits of in periodontal treatment.
牙周炎是一种破坏牙齿支持组织的慢性炎症性疾病。传统的非手术治疗方法，如机械刮治和根面平整（RSD），由于其在完全根除致病微生物方面的疗效有限，往往需要辅助治疗来提高治疗效果。鉴于标准辅助治疗方法（包括抗生素和非甾体抗炎药）的不良反应，鼠尾草因其抗炎和抗菌特性而成为一种有前景的草药替代品。本研究旨在评估丹参凝胶作为刮治和RSD的辅助手段治疗牙周炎的局部应用效果。方法：我们进行了一项随机对照的半口临床试验，纳入了14名全身健康的牙周炎患者。纳入标准为至少有20颗天然牙、至少五个部位的探诊袋深度（PPD）≥5mm且附着丧失≥4mm的患者。测量的主要结局指标为探诊出血（BOP）、PPD和相对附着水平（RAL）。在RSD后，将凝胶应用于指定的试验部位，而对照部位不接受辅助治疗。在基线和1个月随访时记录临床参数。结果：该队列包括10名男性和4名女性，平均年龄为37.1±5.46岁。在随访时，试验组的平均BOP显著降低（P = 0.0004），而对照组无显著变化（P≥0.05）。从基线到随访，两组的平均PPD和RAL均显著降低，试验组改善更明显。结论：丹参凝胶作为刮治和RSD的辅助手段，可显著改善牙周炎患者的临床牙周参数。其抗炎特性可能是观察到的益处的基础，为传统化学药物提供了一种有效且安全的替代品。需要进一步研究来探索丹参在牙周治疗中的长期效果和治疗益处的潜在机制。
