COLLEGE OF EDUCATION AND THERAPY IN POZNAN, POZNAN, POLAND; MEDICAL AFFAIRS DEPARTMENT, PHYTOPHARM KLĘKA SA, NOWE MIASTO NAD WARTĄ, POLAND.
DEPARTMENT OF CONSERVATIVE DENTISTRY AND ENDODONTICS, POZNAN UNIVERSITY OF MEDICAL SCIENCES, POZNAN, POLAND.
Wiad Lek. 2021;74(7):1737-1749.
Intensive studies on properties of synthetic compounds are simultaneously conducted with studies on the effectiveness and safety of drugs derived from natural compounds. These drugs have been effectively used for years in dentistry, in treatment of inflammatory conditions of the oral cavity and in laryngology, in treatment of pharyngeal inflammatory conditions. The subject of this article is a compilation of studies conducted on medicinal products containing composed ethanolic extract as an active substance, and obtained from: chamomile capitulum (Matricaria recutita L.), oak bark (Quercus spp.), sage leaf (Salvia officinalis L.), arnica herb (Arnica spp.), calamus rhizome (Acorus calamus L.), peppermint herb (Mentha piperita L.), thyme herb (Thymus spp.) Preclinical studies confirmed that a particular tested plant extract exhibits antimicrobial (antibacterial, antifungal and antiprotozoal) as well as anti-inflammatory, immunomodulatory and astringent properties. Under clinical conditions, it was confirmed that drugs containing the analysed extract used in periodontology, in prevention and complex treatment of gingivitis, periodontitis as well as diseases of oral mucosa (but also the throat) of viral, bacterial, fungal and protozoal aetiology significantly improved the effectiveness of therapy, shortened the treatment and improved the patients' quality of life. The above preparations used in dental surgery contributed to faster tissue regeneration, more quickly relieved pain and swelling after a surgery or difficult dentition. Furthermore, drugs containing the above-mentioned extract can also be successfully used for oral cavity decontamination in the case of various diseases of teeth or the oral and pharyngeal mucosa. The tested composed herbal extract (CHE), applied in the form of a mouthwash and in the form for topical application with benzocaine content (CHEB), is a component of drugs which are great alternatives to widely used synthetic drugs. They are characterised with high effectiveness, comparable to that of synthetic agents, and a higher safety profile. Results of pharmacological and clinical studies justify their use in both prevention and treatment of inflammatory diseases of the gums, periodontium, oral cavity and pharynx.
同时对合成化合物的性质进行深入研究，并对天然化合物衍生药物的有效性和安全性进行研究。这些药物在牙科、治疗口腔炎症和喉科学、治疗咽部炎症方面已经有效使用多年。本文的主题是对含有复合醇提物作为活性物质的药物进行的研究的汇编，这些药物来自：洋甘菊花（Matricaria recutita L.）、橡树皮（Quercus spp.）、鼠尾草叶（Salvia officinalis L.）、山金车花属植物（Arnica spp.）、菖蒲根（Acorus calamus L.）、薄荷草（Mentha piperita L.）、百里香草（Thymus spp.）。 临床前研究证实，特定测试的植物提取物具有抗菌（抗细菌、抗真菌和抗原生动物）以及抗炎、免疫调节和收敛特性。在临床条件下，证实含有分析提取物的药物在牙周病学中，在预防和综合治疗牙龈炎、牙周炎以及口腔粘膜（也包括喉咙）的病毒、细菌、真菌和原生动物病因学疾病方面，显著提高了治疗效果，缩短了治疗时间，并提高了患者的生活质量。在牙科手术中使用的上述制剂有助于更快地组织再生，在手术后或困难的牙齿更迅速地缓解疼痛和肿胀。此外，含有上述提取物的药物还可成功用于各种牙齿或口腔和咽粘膜疾病的口腔净化。经测试的复方草药提取物（CHE），以漱口剂的形式和含有苯佐卡因含量的局部应用形式（CHEB），是广泛使用的合成药物的替代品的药物成分。它们具有高效性，与合成药物相当，并且具有更高的安全性。药理和临床研究的结果证明了它们在预防和治疗牙龈、牙周炎、口腔和咽部炎症性疾病方面的应用。
