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肌肉骨骼疾病与更年期

Musculoskeletal Disorders and Menopause.

作者信息

Khadilkar Suvarna Satish

机构信息

Bombay Hospital and Medical Research Centre, 12 New Marine Line, Mumbai, 400020 India.

出版信息

J Obstet Gynaecol India. 2019 Apr;69(2):99-103. doi: 10.1007/s13224-019-01213-7. Epub 2019 Mar 7.

Abstract

Menopause has an adverse impact on overall musculoskeletal health. It is associated with osteoporosis, osteoarthritis and Sarcopenia. Sarcopenia includes age-related muscle wasting as well as loss of muscle function. It is a relatively newly recognized condition and is known to be accelerated by estrogen deficiency. Osteoarthritis is also linked with estrogen deficiency more recently. Locomotor disability leads to a compromised quality of life. Sarcopenia and obesity (sarcobesity) have adverse outcome as it leads to morbidity due to increased incidence of lifestyle diseases like diabetes mellitus, hypertension. Poor musculoskeletal health may progress to frailty and higher incidence of falls and fractures which further increase associated morbidity and mortality. The healthcare providers and policy makers need to focus on this group of disorders and include its prevention in national program to reduce the health resources utilization.

摘要

更年期对整体肌肉骨骼健康有不利影响。它与骨质疏松症、骨关节炎和肌肉减少症有关。肌肉减少症包括与年龄相关的肌肉萎缩以及肌肉功能丧失。这是一种相对较新认识到的病症,已知会因雌激素缺乏而加速发展。骨关节炎最近也与雌激素缺乏有关。运动功能障碍会导致生活质量下降。肌肉减少症和肥胖症(肌少肥胖症)会产生不良后果,因为它会导致诸如糖尿病、高血压等生活方式疾病发病率增加,进而引发发病。肌肉骨骼健康不佳可能会发展为身体虚弱以及跌倒和骨折的发生率升高,这会进一步增加相关的发病率和死亡率。医疗保健提供者和政策制定者需要关注这组疾病,并将其预防纳入国家计划,以减少卫生资源的利用。

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引用本文的文献

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Osteoporosis and sarcopenia: two diseases or one?骨质疏松症与肌少症:两种疾病还是一种?
Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):31-6. doi: 10.1097/MCO.0000000000000230.
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Associations of menopausal vasomotor symptoms with fracture incidence.绝经后血管舒缩症状与骨折发生率的关联。
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Osteoporos Int. 2014 Oct;25(10):2359-81. doi: 10.1007/s00198-014-2794-2. Epub 2014 Aug 15.
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SARC-F: a simple questionnaire to rapidly diagnose sarcopenia.SARC-F:一种用于快速诊断肌肉减少症的简易问卷。
J Am Med Dir Assoc. 2013 Aug;14(8):531-2. doi: 10.1016/j.jamda.2013.05.018. Epub 2013 Jun 25.
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'Sarcobesity': a metabolic conundrum.“Sarcobesity”:一种代谢难题。
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Menopause and sarcopenia: A potential role for sex hormones.绝经与肌少症:性激素的潜在作用。
Maturitas. 2011 Apr;68(4):331-6. doi: 10.1016/j.maturitas.2011.01.014. Epub 2011 Feb 25.

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