Department of Surgery, Brandon Regional Hospital, HCA Healthcare/ USF Morsani College of Medicine GME, Brandon, Florida.
Department of Surgery, Brandon Regional Hospital, HCA Healthcare/ USF Morsani College of Medicine GME, Brandon, Florida.
J Surg Res. 2021 May;261:105-112. doi: 10.1016/j.jss.2020.12.026. Epub 2021 Jan 7.
Invasive papillary carcinoma (IPC) of the breast is thought to carry a more favorable prognosis than invasive ductal carcinoma (IDC). The aim of this study is to investigate the clinicopathological characteristics between IPC and IDC and their prognosis using a large nationwide data set.
Female patients diagnosed with malignant IPC and IDC between 2005 and 2014 were analyzed. Patients with incomplete survival data, stage 0/IV, unknown stage, or recurrent disease were excluded. Five-year overall survival was compared between IPC and IDC.
Among 308,426 patients, 1147 had IPC and 307,279 had IDC. IPC presented more in older postmenopausal women, black Americans, and people who had government insurance. IPC had larger tumor size, lower-grade, and earlier-stage disease, less node-positive disease, higher hormone positivity, and lower human epidermal growth factor receptor 2 amplification. Adjuvant radiation and chemotherapy rates were lower in IPC than those in IDC. IPC had a similar 5-year overall survival as compared with IDC overall (86.8% versus 88.7%) (P = 0.06). Age, pathologic stage, and radiation treatment were shown to be independent prognostic factors of IPC.
IPC has a similar prognosis as IDC, suggesting that these patients should follow the same treatment protocols.
浸润性乳头状癌（IPC）被认为比浸润性导管癌（IDC）预后更好。本研究旨在使用大型全国性数据集探讨 IPC 和 IDC 的临床病理特征及其预后。
分析 2005 年至 2014 年间诊断为恶性 IPC 和 IDC 的女性患者。排除生存数据不完整、分期 0/IV、分期未知或复发的患者。比较 IPC 和 IDC 的 5 年总生存率。
在 308426 名患者中，1147 名患者患有 IPC，307279 名患者患有 IDC。IPC 多见于老年绝经后妇女、黑人和拥有政府保险的人群。IPC 肿瘤较大，分级较低，分期较早，淋巴结阳性病变较少，激素阳性率较高，人表皮生长因子受体 2 扩增率较低。与 IDC 相比，IPC 辅助放疗和化疗率较低。IPC 的 5 年总生存率与 IDC 总体生存率相似（86.8%对 88.7%）（P=0.06）。年龄、病理分期和放疗被证明是 IPC 的独立预后因素。
IPC 的预后与 IDC 相似，提示这些患者应遵循相同的治疗方案。
