Department of Cardiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.
Clin Interv Aging. 2024 May 13;19:817-825. doi: 10.2147/CIA.S461832. eCollection 2024.
The role of total bilirubin (TBIL) in cardiovascular disease has been increasingly recognized in recent decades. Studies have shown a correlation between total bilirubin levels and the prognosis of patients after heart surgery. This study aimed to investigate the clinical significance of bilirubin elevation in persistent atrial fibrillation (PAF) patients who received radiofrequency catheter ablation (RFCA).
A total of 184 patients with PAF who received RFCA were retrospectively studied. Laboratory examinations and demographic data were analyzed to identify independent predictors of TBIL elevation. The relationship between TBIL and prognosis was further investigated. Our results indicated that TBIL increased significantly after RFCA. Multiple linear regression analysis showed that TBIL elevation owned a negative correlation with the percentile of low voltage areas (LVAs) in left atria (β=-0.490, P<0.001). In contrast, a positive correlation was observed with the white blood cell (WBC) ratio (β=0.153, P=0.042) and left atrial diameter (LAD) (β=0.232, P=0.025). It was found that postoperative TBIL levels increased and then gradually decreased to baseline within 5 days without intervention. The bilirubin ratio <1.211 indicated the possibility of 1-year AF recurrence after ablation with a predictive value of 0.743 (specificity = 75.00%, sensitivity = 66.67%).
Bilirubin elevation post PAF RFCA was a common phenomenon and was associated with 1-year recurrence of AF in PAF patients after RFCA.
近几十年来，总胆红素（TBIL）在心血管疾病中的作用越来越受到重视。研究表明，总胆红素水平与心脏手术后患者的预后之间存在相关性。本研究旨在探讨射频导管消融（RFCA）后持续性心房颤动（PAF）患者胆红素升高的临床意义。
回顾性研究了 184 例接受 RFCA 的 PAF 患者。分析实验室检查和人口统计学数据，以确定 TBIL 升高的独立预测因素。进一步研究了 TBIL 与预后的关系。结果表明，RFCA 后 TBIL 显著升高。多元线性回归分析显示，TBIL 升高与左心房（LVA）低电压区（LVAs）的百分比呈负相关（β=-0.490，P<0.001）。相反，与白细胞（WBC）比值（β=0.153，P=0.042）和左心房直径（LAD）（β=0.232，P=0.025）呈正相关。结果发现，术后 TBIL 水平升高，然后在无干预的情况下，在 5 天内逐渐降至基线。胆红素比值<1.211 提示消融后 1 年 AF 复发的可能性，预测值为 0.743（特异性=75.00%，敏感性=66.67%）。
PAF RFCA 后胆红素升高是一种常见现象，与 RFCA 后 PAF 患者 1 年 AF 复发有关。
