Pappachan Joseph M, Fernandez Cornelius James, Ashraf Ambika P
Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.
Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom.
World J Diabetes. 2024 May 15;15(5):797-809. doi: 10.4239/wjd.v15.i5.797.
Childhood-onset obesity has emerged as a major public healthcare challenge across the globe, fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions. This has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and adolescents. The looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most countries. Unless there is a collective global effort to curb the devastation caused by the situation, the impact is poised to be pro-found. A multifaceted research effort, governmental legislation, and effective social action are crucial in attaining this goal. This article delves into the current epidemiological landscape, explores evidence concerning potential risks and consequences, delves into the pathobiology of childhood obesity, and discusses the latest evidence-based management strategies for diabesity.
儿童期肥胖已成为全球主要的公共卫生挑战，在致胖环境的推动下，受遗传和表观遗传易感性的影响。这导致儿童和青少年2型糖尿病的发病率呈指数级上升。预计成年早期即将出现的与糖尿病相关的并发症浪潮将使大多数国家的医疗预算不堪重负。除非全球共同努力遏制这种情况造成的破坏，否则其影响将是深远的。多方面的研究努力、政府立法和有效的社会行动对于实现这一目标至关重要。本文深入探讨了当前的流行病学情况，探索了有关潜在风险和后果的证据，深入研究了儿童肥胖的病理生物学，并讨论了糖尿病肥胖症的最新循证管理策略。
