Center for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL.
Circ Genom Precis Med. 2024 Jun;17(3):e004398. doi: 10.1161/CIRCGEN.123.004398. Epub 2024 May 20.
Omics refers to the measurement and analysis of the totality of molecules or biological processes involved within an organism. Examples of omics data include genomics, transcriptomics, epigenomics, proteomics, metabolomics, and more. In this review, we present the available literature reporting omics data on heart failure that can inform the development of novel treatments or innovative treatment strategies for this disease. This includes polygenic risk scores to improve prediction of genomic data and the potential of multiomics to more efficiently identify potential treatment targets for further study. We also discuss the limitations of omic analyses and the barriers that must be overcome to maximize the utility of these types of studies. Finally, we address the current state of the field and future opportunities for using multiomics to better personalize heart failure treatment strategies.
组学是指对生物体内部涉及的所有分子或生物过程的测量和分析。组学数据的例子包括基因组学、转录组学、表观基因组学、蛋白质组学、代谢组学等。在这篇综述中，我们呈现了可用于心力衰竭的组学数据的现有文献，这些数据可以为这种疾病的新疗法或创新治疗策略的发展提供信息。这包括多基因风险评分以提高对基因组数据的预测，以及多组学在更有效地识别潜在治疗靶点以进一步研究方面的潜力。我们还讨论了组学分析的局限性以及必须克服的障碍，以最大限度地提高这类研究的效用。最后，我们讨论了该领域的现状以及使用多组学更好地实现心力衰竭治疗策略个体化的未来机会。
