Yan Zhuojun, Yao Mengmeng, Zhao Zhongming, Yang Qi, Liu Rui, Liu Baijun, Wang Xueyu, Chen Liming, Zhang Hong, Wei Yuping, Yao Fanglian, Li Junjie
School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Biomedical Engineering Cockrell School of Engineering, University of Texas at Austin, Austin, TX, 78712, USA.
Adv Healthc Mater. 2024 Aug;13(20):e2400126. doi: 10.1002/adhm.202400126. Epub 2024 May 30.
Blood-contact medical devices are indispensable for clinical interventions, yet their susceptibility to thrombosis and bacterial infections poses substantial risks to treatment efficacy and patient well-being. This study introduces a polysulfobetaine/alginate-Cu (SAC) zwitterionic hydrogel coating on polyurethane (PU) surfaces. This approach retains the superhydrophilic and antifouling nature of pSBMA while conferring the antibacterial effects of copper ions. Meanwhile, the copper alginate network intertwines with the polysulfobetaine (pSBMA) network, enhancing its mechanical properties and overcoming inherent weaknesses, thereby improving coating durability. Compared to the substrate, the SAC hydrogel coating significantly reduces thrombus adhesion mass by approximately 81.5% during extracorporeal blood circulation and effectively prevents bacterial biofilm formation even in a high-concentration bacterial milieu over 30 days. Moreover, the results from an isolated blood circulation model in New Zealand white rabbits affirm the impressive anticoagulant efficacy of the SAC hydrogel coating. The findings suggest that this hydrogel coating and its application method hold promise as a solution for blood-contact material surface modification to address thrombosis and bacterial biofilm formation simultaneously.
血液接触型医疗设备对于临床干预不可或缺，然而它们易引发血栓形成和细菌感染，这对治疗效果和患者健康构成了重大风险。本研究在聚氨酯（PU）表面引入了一种聚磺酸甜菜碱/海藻酸铜（SAC）两性离子水凝胶涂层。这种方法保留了聚磺酸甜甲基丙烯酸酯（pSBMA）的超亲水性和抗污性，同时赋予了铜离子抗菌效果。与此同时，海藻酸铜网络与聚磺酸甜菜碱（pSBMA）网络相互交织，增强了其机械性能并克服了固有弱点，从而提高了涂层的耐久性。与基材相比，SAC水凝胶涂层在体外血液循环过程中可使血栓粘附量显著降低约81.5%，并且即使在超过30天的高浓度细菌环境中也能有效防止细菌生物膜形成。此外，新西兰白兔离体血液循环模型的结果证实了SAC水凝胶涂层具有令人印象深刻的抗凝效果。研究结果表明，这种水凝胶涂层及其应用方法有望作为一种解决方案，用于血液接触材料表面改性，以同时解决血栓形成和细菌生物膜形成问题。
