Nemirova Svetlana, Orlova Anna, Kurnikov Alexey, Litvinova Yulia, Kazakov Viacheslav, Ayvazyan Irina, Liu Yu-Hang, Razansky Daniel, Subochev Pavel
Privolzhsky Research Medical University, 10/1 Minin & Pozharsky sq., Nizhny Novgorod 603950, Russia.
A.V. Gaponov-Grekhov Institute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, Russia.
Photoacoustics. 2024 May 7;38:100616. doi: 10.1016/j.pacs.2024.100616. eCollection 2024 Aug.
This study highlights the potential of scanning optoacoustic angiography (OA) in identifying alterations of superficial vasculature in patients with post-thrombotic syndrome (PTS) of the foot, a venous stress disorder associated with significant morbidity developing from long-term effects of deep venous thrombosis. The traditional angiography methods available in the clinics are not capable of reliably assessing the state of peripheral veins that provide blood outflow from the skin, a key hallmark of personalized risks of PTS formation after venous thrombosis. Our findings indicate that OA can detect an increase in blood volume, diameter, and tortuosity of superficial blood vessels. The inability to spatially separate vascular plexuses of the dermis and subcutaneous adipose tissue serves as a crucial criterion for distinguishing PTS from normal vasculature. Furthermore, our study demonstrates the ability of scanning optoacoustic angiography to detect blood filling decrease in an elevated limb position versus increase in a lowered position.
本研究强调了扫描光声血管造影（OA）在识别足部血栓后综合征（PTS）患者浅表血管系统改变方面的潜力，PTS是一种静脉应激障碍，由深静脉血栓形成的长期影响导致显著的发病率。临床现有的传统血管造影方法无法可靠地评估从皮肤流出血液的外周静脉状态，而这是静脉血栓形成后PTS个性化风险的一个关键标志。我们的研究结果表明，OA能够检测到浅表血管的血容量、直径和迂曲度增加。无法在空间上区分真皮和皮下脂肪组织的血管丛是区分PTS与正常血管系统的关键标准。此外，我们的研究证明了扫描光声血管造影能够检测到肢体抬高时血液充盈减少，而在肢体降低时血液充盈增加。
