Kočišová Eva, Kuižová Alžbeta, Procházka Marek
Charles University, Faculty of Mathematics and Physics, Institute of Physics, Ke Karlovu 5, 121 16 Prague 2, Czech Republic.
Analyst. 2024 Jun 10;149(12):3276-3287. doi: 10.1039/d4an00336e.
The droplet deposition methods in Raman spectroscopy have received considerable attention in the field of analytical sensing focusing on effective pre-concentration of the studied analyte (coffee-ring effect or small spots). This review covers different analytical applications of drop-coating deposition Raman scattering (DCDRS) and droplet deposition surface-enhanced Raman scattering (SERS) spectroscopy. Two main advantages of droplet deposition Raman techniques are considered: the drying-induced segregation of the components from the mixtures (such as body fluids) and the sensitivity of detection of various analytically important molecules. Some recent advanced applications, including clinical cancer diagnosis, are discussed and summarized. Finally, the potential and further perspectives of the droplet deposition Raman methods for analytical studies are introduced.
拉曼光谱中的液滴沉积方法在分析传感领域备受关注，该领域主要聚焦于对研究分析物的有效预浓缩（咖啡环效应或小斑点）。本综述涵盖了滴涂沉积拉曼散射（DCDRS）和液滴沉积表面增强拉曼散射（SERS）光谱的不同分析应用。文中考虑了液滴沉积拉曼技术的两个主要优点：混合物（如体液）中各成分因干燥而产生的分离，以及对各种具有重要分析意义的分子的检测灵敏度。文中讨论并总结了一些近期的先进应用，包括临床癌症诊断。最后，介绍了液滴沉积拉曼方法在分析研究中的潜力和进一步的前景。
