Sear J W, Uppington J, Kay N H
Postgrad Med J. 1985;61 Suppl 3:165-8.
The influence of an emulsion formulation of 2,6-diisopropylphenol (propofol) on blood coagulation and fibrinolysis, and on the neuroendocrine responses to surgery has been investigated in 12 patients who received incremental doses of propofol to supplement 67% nitrous oxide in oxygen as anaesthesia for body surface surgery. The effects were compared with those in 10 patients who received Althesin to supplement nitrous oxide in oxygen in a similar manner. When pre-operative values were compared with data obtained after 30 min surgery, no significant effects on coagulation or fibrinolytic indices were found in either group. Both groups, however, showed a significant fall in haemoglobin concentration 30 min after induction of anaesthesia (P less than 0.05); and a fall in haematrocrit value was observed in those patients who received propofol (P less than 0.05). No changes in total white cell counts or platelet counts were observed. Both groups of patients showed a significant rise in blood glucose 30 min after induction of anaesthesia (P less than 0.001). After 3 h values were not significantly different from preoperative levels. The mean plasma cortisol levels fell in both groups 30 min after induction of anaesthesia, but returned to control values by 3 h. The mechanism causing this decrease is not known.
已对12例接受递增剂量异丙酚以补充67%氧化亚氮 - 氧气用于体表手术麻醉的患者，研究了2,6 - 二异丙基苯酚（异丙酚）乳剂配方对凝血和纤溶的影响，以及对手术神经内分泌反应的影响。将这些影响与10例以类似方式接受阿法沙龙补充氧化亚氮 - 氧气的患者的影响进行了比较。当将术前值与手术30分钟后获得的数据进行比较时，两组均未发现对凝血或纤溶指标有显著影响。然而，两组在麻醉诱导后30分钟血红蛋白浓度均显著下降（P小于0.05）；接受异丙酚的患者观察到血细胞比容值下降（P小于0.05）。未观察到白细胞总数或血小板计数的变化。两组患者在麻醉诱导后30分钟血糖均显著升高（P小于0.001）。3小时后的值与术前水平无显著差异。两组患者在麻醉诱导后30分钟血浆皮质醇平均水平均下降，但在3小时时恢复到对照值。导致这种下降的机制尚不清楚。
