Luo Pei, Li Ying-Ying, Huang Can, Guo Jun, Yao Xin
Department of Gastroenterology, People's Hospital of Qianxinan Prefecture, Xingyi, Guizhou, 562400, China.
Department of Gerontology, People's Hospital of Qianxinan Prefecture, Xingyi, Guizhou, 562400, China.
Discov Oncol. 2024 May 21;15(1):179. doi: 10.1007/s12672-024-01042-9.
The aim of this study is to enhance the accuracy of monitoring and treatment information for patients diagnosed with colorectal cancer (CRC).
Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, a cohort of 335,948 eligible CRC patients was included in this investigation. Conditional survival probability and actuarial overall survival were employed as methodologies to investigate the association between clinicopathological characteristics and cancer prognosis.
Among CRC patients, the 5-year survival rate was 59%, while the 10-year survival rate was 42%. Over time, conditional survival showed a consistent increase, with rates reaching 45% and 48% for individuals surviving 1 and 2 years, respectively. Notably, patients with unfavorable tumor stages exhibited substantial improvements in conditional survival, thereby narrowing the disparity with actuarial overall survival over time.
This study underscores the significance of time-dependent conditional survival probability, particularly for patients with a poorer prognosis. The findings suggest that long-term CRC survivors may experience improved cancer prognosis over time.
本研究的目的是提高结直肠癌（CRC）患者监测和治疗信息的准确性。
利用监测、流行病学和最终结果（SEER）数据库，本研究纳入了335948例符合条件的CRC患者队列。采用条件生存概率和精算总生存率作为方法来研究临床病理特征与癌症预后之间的关联。
在CRC患者中，5年生存率为59%，10年生存率为42%。随着时间的推移，条件生存呈持续上升趋势，存活1年和2年的个体的条件生存率分别达到45%和48%。值得注意的是，肿瘤分期不利的患者的条件生存有显著改善，从而随着时间的推移缩小了与精算总生存率的差距。
本研究强调了时间依赖性条件生存概率的重要性，特别是对于预后较差的患者。研究结果表明，长期CRC幸存者随着时间的推移可能会有更好的癌症预后。
