Nouri-Aria K T, Donaldson P T, Hegarty J E, Eddleston A L, Williams R
J Hepatol. 1985;1(3):235-41. doi: 10.1016/s0168-8278(85)80051-9.
The relationship between suppressor T cell function and the inheritance of the A1, B8, DR3 haplotype was studied in 17 healthy, first-degree relatives of patients with autoimmune chronic active hepatitis. A marked defect in suppressor cell function was found significantly more often in A1, B8, DR3-positive relatives (5 of 7) compared with those who were A1, B8, DR3-negative (1 of 10; P = 0.017). Less marked abnormalities were also found in the A1, B8, DR3-negative relatives compared with A1, B8, DR3-negative control subjects. The results indicate that the defects in suppressor cell function in patients with untreated chronic active hepatitis result from the inheritance of genetic factors linked to the major histocompatibility complex and other gene loci and are not secondary to hepatic inflammation.
对17名自身免疫性慢性活动性肝炎患者的健康一级亲属进行了研究，以探讨抑制性T细胞功能与A1、B8、DR3单倍型遗传之间的关系。与A1、B8、DR3阴性的亲属（10人中1人；P = 0.017）相比，A1、B8、DR3阳性的亲属（7人中5人）中明显更常发现抑制细胞功能存在显著缺陷。与A1、B8、DR3阴性的对照受试者相比，A1、B8、DR3阴性的亲属中也发现了不太明显的异常。结果表明，未经治疗的慢性活动性肝炎患者抑制细胞功能的缺陷是由与主要组织相容性复合体和其他基因位点相关的遗传因素遗传所致，而非继发于肝脏炎症。
