Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.
Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.
Signal Transduct Target Ther. 2022 Jun 13;7(1):186. doi: 10.1038/s41392-022-01043-6.
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has dramatically influenced various aspects of the world. It is urgent to thoroughly study pathology and underlying mechanisms for developing effective strategies to prevent and treat this threatening disease. It is universally acknowledged that cell death and cell autophagy are essential and crucial to maintaining host homeostasis and participating in disease pathogenesis. At present, more than twenty different types of cell death have been discovered, some parts of which have been fully understood, whereas some of which need more investigation. Increasing studies have indicated that cell death and cell autophagy caused by coronavirus might play an important role in virus infection and pathogenicity. However, the knowledge of the interactions and related mechanisms of SARS-CoV-2 between cell death and cell autophagy lacks systematic elucidation. Therefore, in this review, we comprehensively delineate how SARS-CoV-2 manipulates diverse cell death (including apoptosis, necroptosis, pyroptosis, ferroptosis, and NETosis) and cell autophagy for itself benefits, which is simultaneously involved in the occurrence and progression of COVID-19, aiming to provide a reasonable basis for the existing interventions and further development of novel therapies.
当前由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的 2019 年冠状病毒病（COVID-19）大流行极大地影响了世界的各个方面。迫切需要深入研究病理学和潜在机制，以制定预防和治疗这种威胁性疾病的有效策略。人们普遍认为，细胞死亡和细胞自噬对于维持宿主内稳态和参与疾病发病机制至关重要。目前，已经发现了二十多种不同类型的细胞死亡，其中一些已经得到了充分的了解，而另一些则需要更多的研究。越来越多的研究表明，冠状病毒引起的细胞死亡和细胞自噬可能在病毒感染和致病性中起重要作用。然而，关于 SARS-CoV-2 与细胞死亡和细胞自噬之间相互作用及相关机制的知识还缺乏系统的阐述。因此，在这篇综述中，我们全面描述了 SARS-CoV-2 如何为自身利益操纵多种细胞死亡（包括细胞凋亡、坏死性凋亡、细胞焦亡、铁死亡和 NETosis）和细胞自噬，同时涉及 COVID-19 的发生和进展，旨在为现有的干预措施和新型治疗方法的进一步发展提供合理依据。
