Rødland O, Markestad T, Aksnes L, Aarskog D
Diabetologia. 1985 Sep;28(9):663-6. doi: 10.1007/BF00291972.
Plasma concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D and vitamin D binding protein were determined in 87 serum samples from 46 Type 1 (insulin-dependent) diabetic children and adolescents at the various stages of puberty. The results were compared with data similarly obtained from healthy pubertal children. The diabetic patients had lower mean 1,25-dihydroxyvitamin D concentrations (p less than 0.05) and higher molar ratios of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (p less than 0.05) than their healthy counter parts. In contrast to the reference group, the diabetic patients failed to attain the increase in 1,25-dihydroxyvitamin D normally seen during the pubertal stages of maximal growth velocity. The mean plasma levels of vitamin-D binding protein did not differ between the two groups, and a calculated 'free' 1,25-dihydroxyvitamin D value followed a pattern similar to that of total 1,25-dihydroxyvitamin D throughout puberty for both groups. The results suggest that the regulatory mechanisms of the vitamin D endocrine system are altered in diabetic children at puberty, resulting in a relative decrease in 1,25-dihydroxyvitamin D plasma concentration and increased 24,25-dihydroxyvitamin D levels.
对46名1型（胰岛素依赖型）糖尿病儿童和青少年在青春期各个阶段的87份血清样本，测定了血浆中25-羟基维生素D、1,25-二羟基维生素D、24,25-二羟基维生素D和维生素D结合蛋白的浓度。将结果与从健康青春期儿童中同样获得的数据进行比较。糖尿病患者的平均1,25-二羟基维生素D浓度较低（p小于0.05），24,25-二羟基维生素D与25-羟基维生素D的摩尔比高于其健康对照者（p小于0.05）。与参照组不同，糖尿病患者在最大生长速度的青春期阶段未能出现正常情况下1,25-二羟基维生素D的增加。两组间维生素D结合蛋白的平均血浆水平无差异，且两组在整个青春期计算得出的“游离”1,25-二羟基维生素D值与总1,25-二羟基维生素D值的变化模式相似。结果表明，青春期糖尿病儿童维生素D内分泌系统的调节机制发生改变，导致1,25-二羟基维生素D血浆浓度相对降低，24,25-二羟基维生素D水平升高。
