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艾滋病患者体内的循环免疫球蛋白A免疫复合物

Circulating IgA immune complexes in AIDS.

作者信息

Lightfoote M M, Folks T M, Redfield R, Gold J, Sell K W

出版信息

Immunol Invest. 1985 Aug;14(4):341-5. doi: 10.3109/08820138509022669.

DOI:10.3109/08820138509022669
PMID:3877683
Abstract

Circulating immune complexes were isolated from the serum of patients with AIDS, as well as patients with other acute and chronic viral diseases. Analysis of these immune complexes by methods of flow cytometry and by radioimmune (Raji cell) assay revealed a prevalence of IgA complexes in the serum of AIDS patients and a prevalence of IgG complexes in the serum of patients with other viral diseases. Raji cells bind immune complexes via Fc and complement (C3) receptors and may detect IgA immune complexes more efficiently than a C1q assay since IgA has no affinity for C1q.

摘要

从艾滋病患者以及其他急慢性病毒性疾病患者的血清中分离出循环免疫复合物。通过流式细胞术和放射免疫(拉吉细胞)测定法对这些免疫复合物进行分析,结果显示艾滋病患者血清中以IgA复合物为主,而其他病毒性疾病患者血清中以IgG复合物为主。拉吉细胞通过Fc和补体(C3)受体结合免疫复合物,并且由于IgA对C1q没有亲和力,所以它可能比C1q测定法更有效地检测IgA免疫复合物。

相似文献

1
Circulating IgA immune complexes in AIDS.艾滋病患者体内的循环免疫球蛋白A免疫复合物
Immunol Invest. 1985 Aug;14(4):341-5. doi: 10.3109/08820138509022669.
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Circulating IgA immune complexes in patients with psoriasis.银屑病患者循环中的IgA免疫复合物
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IgA-containing circulating immune complexes in patients with igA nephropathy.IgA肾病患者中含IgA的循环免疫复合物。
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IgA1 is the major immunoglobulin component of immune complexes in the acquired immune deficiency syndrome.IgA1是获得性免疫缺陷综合征中免疫复合物的主要免疫球蛋白成分。
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Application of the solid phase C1q and Raji cell radioimmune assays for the detection of circulating immune complexes in glomerulonephritis.固相C1q和拉吉细胞放射免疫分析法在肾小球肾炎循环免疫复合物检测中的应用。
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Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy.原发性IgA肾病循环IgA分析及免疫复合物检测
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[Determination of circulating immune complexes and of their component immunoglobulin classes M, G, and A with a C1q-ELISA].[用C1q酶联免疫吸附测定法测定循环免疫复合物及其免疫球蛋白M、G和A组分]
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J Clin Immunol. 1994 Sep;14(5):259-72. doi: 10.1007/BF01540979.
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The Vancouver Lymphadenopathy-AIDS Study: 7. Clinical and laboratory features of 87 cases of primary HIV infection.温哥华淋巴结病-艾滋病研究:7. 87例原发性HIV感染的临床和实验室特征。
CMAJ. 1987 Jul 15;137(2):109-13.
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Evidence for activation of complement in patients with AIDS related complex (ARC) and/or lymphoadenopathy syndrome (LAS).艾滋病相关综合征(ARC)和/或淋巴结病综合征(LAS)患者补体激活的证据。
Clin Exp Immunol. 1987 Dec;70(3):500-7.
6
IgA1 is the major immunoglobulin component of immune complexes in the acquired immune deficiency syndrome.IgA1是获得性免疫缺陷综合征中免疫复合物的主要免疫球蛋白成分。
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J Clin Immunol. 1988 Sep;8(5):390-6. doi: 10.1007/BF00917155.
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