Jackson S, Dawson L M, Kotler D P
Department of Microbiology, University of Alabama, Birmingham 35294.
J Clin Immunol. 1988 Jan;8(1):64-8. doi: 10.1007/BF00915158.
Compared to a panel of healthy controls, sera from 13 of 23 (57%) patients with the acquired immune deficiency syndrome (AIDS) were shown to have elevated levels of circulating immune complexes (CIC) containing IgA. Levels of IgG-containing CIC were increased in seven patients (30%); no patients had elevated levels of IgM-containing CIC. Additional experiments showed that in all instances in which IgG CIC were demonstrable, IgA was also present; however, IgA CIC could be found that did not contain IgG. The IgA in the CIC was restricted to the IgA1 subclass. These data suggest selective abnormalities of IgA regulation in AIDS and raise questions as to the role in this disease of the immunoglobulin isotype usually thought to possess different protective mechanisms from those attributed to other isotypes.
与一组健康对照相比，23例获得性免疫缺陷综合征（AIDS）患者中有13例（57%）的血清显示含有IgA的循环免疫复合物（CIC）水平升高。7例患者（30%）含IgG的CIC水平升高；没有患者含IgM的CIC水平升高。进一步实验表明，在所有可检测到IgG CIC的情况下，也存在IgA；然而，可发现不含IgG的IgA CIC。CIC中的IgA局限于IgA1亚类。这些数据提示AIDS患者存在IgA调节的选择性异常，并引发了关于通常被认为具有与其他同种型不同保护机制的免疫球蛋白同种型在该疾病中的作用的问题。
