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从小牛胸腺中分离纯化具有增加E受体表达活性的小肽。

Isolation and purification of a small peptide with activity of increasing E-receptor expression from calf thymus.

作者信息

Xu C S, Tao K, Zheng D X, Zheng C X, Liu S L

出版信息

Immunol Invest. 1985 Aug;14(4):355-65. doi: 10.3109/08820138509022671.

DOI:10.3109/08820138509022671
PMID:3877684
Abstract

A small peptide of molecular mass lower than 1,000 daltons was isolated and purified from a crude extract of calf thymus. It has been demonstrated to have the activity of increasing E-rosette formation and E-receptor expression of human and porcine T-lymphocytes with three different in vitro assays. Amino acid composition analysis showed that this peptide consists of glutamic acid, aspartic acid and glycine residues at a molecular ratio of 3:3:2. A hypothesis of a multi-factoral and multi-staged mechanism of regulation of thymocyte differentiation and maturation in the thymus is proposed.

摘要

从牛胸腺粗提物中分离并纯化出一种分子量低于1000道尔顿的小肽。通过三种不同的体外试验已证明它具有增加人和猪T淋巴细胞E花环形成及E受体表达的活性。氨基酸组成分析表明，该肽由谷氨酸、天冬氨酸和甘氨酸残基组成，分子比例为3:3:2。提出了胸腺中胸腺细胞分化和成熟调控的多因素、多阶段机制的假说。

相似文献

1
Isolation and purification of a small peptide with activity of increasing E-receptor expression from calf thymus.从小牛胸腺中分离纯化具有增加E受体表达活性的小肽。
Immunol Invest. 1985 Aug;14(4):355-65. doi: 10.3109/08820138509022671.
2
[Stimulation of antibody formation by thymocyte receptor structures separable under the influence of thymus oligopeptide factor].[胸腺寡肽因子影响下可分离的胸腺细胞受体结构对抗体形成的刺激作用]
Fiziol Zh (1978). 1988 May-Jun;34(3):43-7.
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Structural study of circulating thymic factor: a peptide isolated from pig serum. I. Isolation and purification.循环胸腺因子的结构研究：一种从猪血清中分离出的肽。I. 分离与纯化。
J Biol Chem. 1977 Nov 25;252(22):8040-4.
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Isolation and identification of a new thymic peptide from calf thymus.
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M receptor and differentiation of T lymphocytes in the developing human thymus.M受体与人类发育中胸腺内T淋巴细胞的分化
Adv Exp Med Biol. 1988;237:339-44. doi: 10.1007/978-1-4684-5535-9_50.
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Thymic humoral factor gamma 2: purification and amino acid sequence of an immunoregulatory peptide from calf thymus.胸腺体液因子γ2：来自小牛胸腺的一种免疫调节肽的纯化及氨基酸序列
Biochemistry. 1988 May 31;27(11):4066-71. doi: 10.1021/bi00411a024.
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[Studies on thymic peptide factors. I. Isolation, purification and in vitro E-rosette augmentation activity of calf thymic peptide factors].[胸腺肽因子的研究。I. 小牛胸腺肽因子的分离、纯化及体外E-玫瑰花结增强活性]
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[Studies on thymic peptide factors. III. Isolation, purification, biochemical property and E-rosette activity in vitro of porcine thymic factors].[胸腺肽因子的研究。III. 猪胸腺因子的分离、纯化、生化特性及体外E-玫瑰花结活性]
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Purification to apparent homogeneity of a thymocyte specific growth factor from calf thymus.从小牛胸腺中纯化出具有明显均一性的胸腺细胞特异性生长因子。
Biochem Biophys Res Commun. 1984 Apr 30;120(2):420-6. doi: 10.1016/0006-291x(84)91270-1.
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Correlation between enhanced E-rosette formation and spontaneous incorporation of thymidine by bovine thymus lymphocytes.牛胸腺淋巴细胞增强的E花环形成与胸苷的自发掺入之间的相关性。
Vet Immunol Immunopathol. 1981 Jun;2(3):265-71. doi: 10.1016/0165-2427(81)90027-1.

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