声敏工程菌用于抗肿瘤治疗。
Sono-activatable engineered bacteria for antitumor therapy.
机构信息
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
出版信息
Cell Rep Med. 2024 May 21;5(5):101562. doi: 10.1016/j.xcrm.2024.101562.
Bacteria show promising potential in tumor treatment, but safety concerns limit their application. In this issue, Gao et al. develop ultrasound-controlled engineered bacteria through integrating sono-activatable gene circuits, achieving local production and release of therapeutic cargos in tumor.
细菌在肿瘤治疗中显示出巨大的应用潜力，但安全性问题限制了它们的应用。在本期杂志中，高等人通过整合超声激活基因电路，开发出超声控制的工程细菌，实现了治疗药物在肿瘤部位的局部产生和释放。
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