工程化完美（细菌）癌症疗法。
Engineering the perfect (bacterial) cancer therapy.
机构信息
University of Massachusetts, Amherst, Department of Chemical Engineering, 159 Goessmann Laboratory, Amherst, Massachusetts 01003-9303, USA.
出版信息
Nat Rev Cancer. 2010 Nov;10(11):785-94. doi: 10.1038/nrc2934. Epub 2010 Oct 14.
Abstract
Bacterial therapies possess many unique mechanisms for treating cancer that are unachievable with standard methods. Bacteria can specifically target tumours, actively penetrate tissue, are easily detected and can controllably induce cytotoxicity. Over the past decade, Salmonella, Clostridium and other genera have been shown to control tumour growth and promote survival in animal models. In this Innovation article I propose that synthetic biology techniques can be used to solve many of the key challenges that are associated with bacterial therapies, such as toxicity, stability and efficiency, and can be used to tune their beneficial features, allowing the engineering of 'perfect' cancer therapies.
摘要
细菌疗法具有许多独特的治疗癌症的机制，这是标准方法无法实现的。细菌可以特异性地靶向肿瘤，主动穿透组织，易于检测，并能可控地诱导细胞毒性。在过去的十年中，已经证明沙门氏菌、梭状芽孢杆菌和其他属可以控制肿瘤生长并促进动物模型中的存活。在这篇创新文章中，我提出合成生物学技术可以用于解决与细菌疗法相关的许多关键挑战，例如毒性、稳定性和效率，并可用于调整其有益特性，从而实现“完美”癌症疗法的工程设计。
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