Zgheib Nathalie K
Department of Pharmacology & Toxicology, American University of Beirut Faculty of Medicine, Beirut, Lebanon.
Pharmacogenomics. 2017 Sep;18(14):1311-1316. doi: 10.2217/pgs-2017-0122. Epub 2017 Aug 23.
The pharmacogenetics (PGx) laboratory at the Department of Pharmacology and Toxicology at the American University of Beirut Faculty of Medicine was established in October 2007. Several projects on the genetic polymorphisms of drug metabolizing enzymes and transporters with treatment of noncommunicable diseases such as cardiac diseases and cancers are ongoing. We have been applying the 'candidate gene' PGx approach, and recently started using higher throughput analyses. The more recent research projects are geared towards performing more extensive genotyping and including bigger and more representative population samples such as by developing research registries and prospectively following up patients. Furthermore, many technologies and research applications, such as next-generation sequencing and pharmacoepigenetics that complement and enhance PGx research and applications, are being actively pursued.
贝鲁特美国大学医学院药理学与毒理学系的药物遗传学(PGx)实验室于2007年10月成立。目前正在开展多个关于药物代谢酶和转运蛋白基因多态性与心脏病和癌症等非传染性疾病治疗的项目。我们一直在应用“候选基因”PGx方法,最近开始使用更高通量的分析。最近的研究项目旨在进行更广泛的基因分型,并纳入更大、更具代表性的人群样本,例如通过建立研究登记册和对患者进行前瞻性随访。此外,许多补充和加强PGx研究与应用的技术和研究应用,如下一代测序和药物表观遗传学,也在积极推进。