Ilyas Faheem, James Aimen, Khan Shahid, Haider Soban, Ullah Shaukat, Darwish Ghassan, Taqvi Syed Ali Hassan Raza, Ali Rabia, Younas Qadees, Rehman Abdul
Emergency Department, Medcare International Hospital, Gujranwala, PAK.
Medicine, Abbottabad International Medical College, Khyber Medical University, Abbottabad, PAK.
Cureus. 2024 Apr 22;16(4):e58760. doi: 10.7759/cureus.58760. eCollection 2024 Apr.
This systematic review aimed to explore the antimicrobial activity of a silver-containing gelling fiber dressing against multidrug-resistant organisms (MDROs) in wound infections. It particularly focuses on burn wounds and evaluates its potential clinical significance in combating antimicrobial resistance. A comprehensive literature search was conducted across multiple databases over the past ten years. It is used to identify relevant studies addressing MDRO infections in wound care and exploring novel antimicrobial approaches. The included studies underwent rigorous methodological assessment. Additionally, the data were synthesized to evaluate the efficacy of silver-containing dressings in inhibiting MDRO growth and eradicating biofilm-associated bacteria. Moreover, this review revealed that silver-containing dressings have constant in vitro antimicrobial activity against 10 MDROs over seven days in simulated wound fluid. However, inhibitory and bactericidal effects were consistently observed against free-living and biofilm phenotypes. The findings suggest potential clinical significance in managing MDRO infections in wounds. This highlights its role in mitigating treatment failure and antimicrobial resistance. Despite the promising implications for wound management practices, this study acknowledges some limitations. In vitro models and the absence of direct clinical validation have also been included. However, the review explains the importance of new approaches. Nanotechnology has been used to address antimicrobial resistance in wound care. Thus, further research and innovation are needed to improve patient outcomes and combat antimicrobial resistance.
本系统评价旨在探讨含银凝胶纤维敷料对伤口感染中多重耐药菌（MDROs）的抗菌活性。它特别关注烧伤伤口，并评估其在对抗抗菌药物耐药性方面的潜在临床意义。在过去十年中，对多个数据库进行了全面的文献检索。用于识别涉及伤口护理中MDRO感染并探索新型抗菌方法的相关研究。纳入的研究经过了严格的方法学评估。此外，对数据进行了综合分析，以评估含银敷料在抑制MDRO生长和根除生物膜相关细菌方面的疗效。此外，本评价显示，含银敷料在模拟伤口液中对10种MDROs具有持续7天的体外抗菌活性。然而，对游离菌和生物膜表型始终观察到抑制和杀菌作用。研究结果表明在处理伤口中的MDRO感染方面具有潜在的临床意义。这突出了其在减少治疗失败和抗菌药物耐药性方面的作用。尽管对伤口管理实践有潜在的影响，但本研究承认存在一些局限性。体外模型以及缺乏直接的临床验证也包括在内。然而，该评价解释了新方法的重要性。纳米技术已被用于解决伤口护理中的抗菌药物耐药性问题。因此，需要进一步的研究和创新来改善患者预后并对抗抗菌药物耐药性。
