Sieff C A, Emerson S G, Donahue R E, Nathan D G, Wang E A, Wong G G, Clark S C
Science. 1985 Dec 6;230(4730):1171-3. doi: 10.1126/science.3877981.
Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity.
对重组人粒细胞巨噬细胞集落刺激因子（GM-CSF）诱导富含祖细胞的人骨髓中集落形成的能力进行了检测。除了预期的粒细胞-单核细胞集落刺激活性外，重组GM-CSF对红系爆式集落形成单位具有爆式促进活性，还能刺激多能（混合）祖细胞来源的集落。相比之下，重组促红细胞生成活性并不能刺激红系祖细胞。这些实验证明，人GM-CSF具有多系集落刺激活性。
