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德克·佩特,因其开创性的肌肉研究而被铭记。

Dirk Pette, remembered for his pioneering muscle research.

作者信息

Ohlendieck Kay, Mayr Winfried, Kern Helmut, Reggiani Carlo, Fanò-Illic Giorgio, Carraro Ugo

机构信息

Department of Biology, Maynooth University, National University of Ireland, Co. Kildare, Maynooth, Ireland; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Co. Kildare, Maynooth.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna.

出版信息

Eur J Transl Myol. 2024 May 22;34(2):12681. doi: 10.4081/ejtm.2024.12681.

Abstract

It is with great sadness that we learned of the passing of Prof. Dr. Dr. h.c. Dirk Pette. He passed away suddenly and unexpectedly on June 4, 2022. Dirk was an outstanding professor of biochemistry at the University of Konstanz, Germany and an internationally renowned researcher in the field of skeletal muscle biology. His research on electrical stimulation has had a profound impact on our understanding of myofiber type specification and the enormous adaptive potential of skeletal muscle. Under Dirk's leadership, new biological questions in the field of neuromuscular biology have developed into multidisciplinary approaches using advanced physiological, cell biological, and biochemical techniques. Dirk's research laboratory was frequently visited by a large number of national and international collaborators who familiarized themselves with the technically demanding stimulation protocols and bioanalytical techniques to study the intricate details of the highly complex process of fast-to-slow muscle transitions. Importantly, fundamental studies on the physiological effects of changes in innervation patterns on muscle phenotype have provided the scientific evidence base for a variety of innovative clinical applications. The skeletal muscle research community has lost one of its leading figures and an outstanding teacher of protein biochemistry. He leaves an inspiring legacy in the field of basic and applied myology. Dirk will be missed by his colleagues and by many students of neuromuscular biology and beyond.

摘要

我们怀着极其沉痛的心情获悉迪尔克·佩特教授(Dr. Dr. h.c. Dirk Pette)与世长辞。他于2022年6月4日突然意外离世。迪尔克是德国康斯坦茨大学杰出的生物化学教授,也是骨骼肌生物学领域国际知名的研究员。他在电刺激方面的研究对我们理解肌纤维类型的确定以及骨骼肌巨大的适应潜力产生了深远影响。在迪尔克的领导下,神经肌肉生物学领域的新生物学问题已发展为运用先进的生理学、细胞生物学和生物化学技术的多学科研究方法。迪尔克的研究实验室经常有大量国内外合作者来访,他们熟悉技术要求颇高的刺激方案和生物分析技术,以研究快速到慢速肌肉转变这一高度复杂过程的错综复杂细节。重要的是,关于神经支配模式变化对肌肉表型的生理影响的基础研究为各种创新临床应用提供了科学证据基础。骨骼肌研究界失去了一位领军人物和蛋白质生物化学的杰出教师。他在基础和应用肌学领域留下了鼓舞人心的遗产。迪尔克将被他的同事以及众多神经肌肉生物学及其他领域的学生怀念。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b5/11264222/aaa6488cfd09/ejtm-34-2-12681-g001.jpg

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