Department of Gynecology and Obstetrics, Aksaray University Medical School, Aksaray, Turkey.
Department of Obstetrics and Gynecology, Konya City Hospital, Konya, Turkey.
Postgrad Med. 2024 May;136(4):468-473. doi: 10.1080/00325481.2024.2359892. Epub 2024 May 28.
Predictive tests are needed to ensure the development and subsequent follow-up of pre-eclampsia, which is responsible for significant rates of morbidity and mortality during pregnancy. This study aimed to evaluate the predictive value of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score for the severity of preeclampsia.
We retrospectively analyzed the data of women diagnosed with pre-eclampsia at our clinic from January 2019 to January 2023. The control group consisted of normotensive, healthy pregnant women. Women diagnosed with preeclampsia were further evaluated in two groups: those with severe features and those without severe features. The clinical and demographic data of the cases were evaluated. The HALP score was calculated using the first trimester blood parameters of the cases and compared between groups.
The study included 229 patients with preeclampsia and 142 normotensive healthy controls. Of the patients with preeclampsia, 104 (28.1%) had severe features of the disease. The HALP score was significantly higher in the preeclampsia group with severe features than in the control group (6.18 ± 2.66 vs. 3.75 ± 1.86; = 0.006). In multivariate logistic regression analysis, the HALP score (odds ratio: 2.02, 95% confidence interval: 1.10-3.32, = 0.017) was found to be an independent indicator for preeclampsia with severe features. A HALP score of > 4.61 predicted the development of preeclampsia with severe features with a sensitivity of 74.5% and a specificity of 81.3%.
We found a significant correlation between the HALP score and preeclampsia with severe features. The HALP score may be useful in predicting the severity of preeclampsia.
需要预测性测试来确保子痫前期的发展和后续随访，因为它在怀孕期间导致了很高的发病率和死亡率。本研究旨在评估 Hemoglobin, Albumin, Lymphocyte, and Platelet（HALP）评分对子痫前期严重程度的预测价值。
我们回顾性分析了 2019 年 1 月至 2023 年 1 月在我们诊所诊断为子痫前期的女性的数据。对照组由血压正常、健康的孕妇组成。将诊断为子痫前期的女性进一步分为两组：有严重特征的组和没有严重特征的组。评估病例的临床和人口统计学数据。使用病例的早孕期血液参数计算 HALP 评分，并在组间进行比较。
该研究包括 229 例子痫前期患者和 142 例血压正常的健康对照组。在子痫前期患者中，有 104 例（28.1%）有严重特征。严重特征子痫前期组的 HALP 评分明显高于对照组（6.18±2.66 vs. 3.75±1.86； = 0.006）。在多变量逻辑回归分析中，HALP 评分（比值比：2.02，95%置信区间：1.10-3.32， = 0.017）被发现是严重特征子痫前期的独立指标。HALP 评分 > 4.61 预测严重特征子痫前期的发展，具有 74.5%的敏感性和 81.3%的特异性。
我们发现 HALP 评分与严重特征子痫前期之间存在显著相关性。HALP 评分可能有助于预测子痫前期的严重程度。
