Zhou Xue, Zhao Jingtong, Liu Yang, Sun Xiaozhou, Li Xuefeng, Ren Jixiang, Li Qingjie, Han Dong, Pan Ting, Shi Yingqi, Wu Dalong, Chen Xinhua
Changchun University of Chinese Medicine, Changchun, China.
Changchun Central Hospital, Changchun, China.
Front Neurosci. 2024 May 9;18:1387266. doi: 10.3389/fnins.2024.1387266. eCollection 2024.
Evaluating the correlation between serum potassium and Parkinson's disease (PD) in US adults.
A cross-sectional study was conducted on 20,495 adults aged 40 years or older using NHANES data from 2005 to 2020. The study utilized one-way logistic regression and multifactorial logistic regression to examine the correlation between serum potassium levels and PD. Additionally, a smoothed curve fitting approach was employed to assess the concentration-response relationship between serum potassium and PD. Stratified analyses were carried out to investigate potential interactions between serum potassium levels and PD with variables such as age, sex, race, marital status, education, BMI, smoking and medical conditions like coronary, stroke, diabetes, hypertension, and hypercholesterolemia.
In this study, a total of 20,495 participants, comprising 403 PD and 20,092 non-PD individuals, were included. After adjusted for covariates, multivariable logistic regression revealed that high serum potassium level was an independent risk factor for PD (OR:1.86, 95% CI:1.45 ~ 2.39, < 0.01).The linear association between serum potassium and PD was described using fitted smoothing curves. Age, sex, race, education, marital, BMI, coronary, stroke, diabetes, hypertension and hypercholesterolemia were not significantly correlated with this positive connection, according to subgroup analysis and interaction testing (P for interaction >0.05).
Serum potassium levels are elevated in patients with Parkinson's disease compared to non-PD patients. Additional prospective studies are required to explore the significance of serum potassium levels in individuals with Parkinson's disease.
评估美国成年人血清钾与帕金森病（PD）之间的相关性。
利用2005年至2020年的美国国家健康与营养检查调查（NHANES）数据，对20495名40岁及以上的成年人进行了一项横断面研究。该研究采用单因素逻辑回归和多因素逻辑回归来检验血清钾水平与PD之间的相关性。此外，采用平滑曲线拟合方法来评估血清钾与PD之间的浓度-反应关系。进行分层分析，以研究血清钾水平与PD之间潜在的相互作用，这些相互作用涉及年龄、性别、种族、婚姻状况、教育程度、体重指数（BMI）、吸烟以及诸如冠心病、中风、糖尿病、高血压和高胆固醇血症等医疗状况等变量。
本研究共纳入20495名参与者，其中包括403名PD患者和20092名非PD患者。在对协变量进行调整后，多变量逻辑回归显示高血清钾水平是PD的独立危险因素（比值比：1.86，95%置信区间：1.45～2.39，P＜0.01）。用拟合的平滑曲线描述了血清钾与PD之间的线性关联。根据亚组分析和相互作用检验，年龄、性别、种族、教育程度、婚姻状况、BMI、冠心病、中风、糖尿病、高血压和高胆固醇血症与这种正相关无显著相关性（相互作用P＞0.05）。
与非PD患者相比，帕金森病患者的血清钾水平升高。需要进一步的前瞻性研究来探讨血清钾水平在帕金森病患者中的意义。
