Hao Xiaoqian, Li Haiyan, Li Qinglian, Gao Da, Wang Xiaoling, Wu Chunxiao, Wang Qizhang, Zhu Meiling
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong, China.
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Front Nutr. 2024 Jan 5;10:1289238. doi: 10.3389/fnut.2023.1289238. eCollection 2023.
Current evidence on the association between dietary vitamin E intake and the risk of Parkinson's disease (PD) is limited. The aim of the study was to explore the association of dietary vitamin E intake with PD in the United States among adults over 40 years.
We conducted a cross-sectional study with data collected from National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. A total of the sample of 13,340 participants were included. To identify the different characteristics of the participants, we utilized propensity score matching (PSM) to reduce the effects of selection bias and confounding variables. Weighted univariate and multivariable logistic regression were used to examine the association between dietary vitamin E intake and PD before and after matching. Then, restricted cubic spline (RCS) was used to visually describe the possible non-linear relationships. Finally, we employed the subgroup analysis to further investigate the relationship between dietary vitamin E intake and PD.
According to the weighted univariate and multivariable logistic regression analysis, vitamin E intake was inversely associated with the risk of PD before and after matching. The results of RCS analysis revealed no non-linear inverse relationship between vitamin E intake and PD before and after matching. The subgroup analysis showed that age may influence the negative association between vitamin E and PD ( < 0.05 for interaction).
Among participants over 40 years of age, vitamin E intake was negatively associated with the risk of PD. Our data may support the supplementation of vitamin E to be used as an intervention strategy for the occurrence of PD.
目前关于膳食维生素E摄入量与帕金森病（PD）风险之间关联的证据有限。本研究的目的是探讨美国40岁以上成年人膳食维生素E摄入量与PD之间的关联。
我们进行了一项横断面研究，数据来自2009年至2018年的国家健康与营养检查调查（NHANES）。总共纳入了13340名参与者的样本。为了识别参与者的不同特征，我们采用倾向得分匹配（PSM）来减少选择偏倚和混杂变量的影响。加权单变量和多变量逻辑回归用于检验匹配前后膳食维生素E摄入量与PD之间的关联。然后，使用受限立方样条（RCS）直观地描述可能的非线性关系。最后，我们进行亚组分析以进一步研究膳食维生素E摄入量与PD之间的关系。
根据加权单变量和多变量逻辑回归分析，匹配前后维生素E摄入量与PD风险呈负相关。RCS分析结果显示，匹配前后维生素E摄入量与PD之间不存在非线性负相关关系。亚组分析表明，年龄可能会影响维生素E与PD之间的负相关关系（交互作用P<0.05）。
在40岁以上的参与者中，维生素E摄入量与PD风险呈负相关。我们的数据可能支持补充维生素E作为预防PD发生的一种干预策略。
