Balakrishnan Grrishma, Bangera Shobith, Balasubramaniyam Kalpana, Thalanjeri Padmini, Beeran Nabeel, Uppinakudru Gurunandan, Soofi Anwar Amemar
Department of Physiology, Yenepoya Medical College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India.
Department of Physiology, AJ Institute of Medical Sciences and Research Centre, Kuntikana, Mangaluru, Karnataka, India.
J Educ Health Promot. 2024 Apr 29;13:160. doi: 10.4103/jehp.jehp_1081_23. eCollection 2024.
The pandemic, coronavirus disease 2019 (COVID-19) has led to a heavy toll on the human health. The aim of this study was to determine the influence of body fat distribution, evolving long-term effect on autonomic function, and its correlation with Chalder Fatigue Severity Score in post-COVID-19-recovered individuals of Indian ethnicity.
A case-control study was conducted in the Department of Physiology on 31 cases and 29 age- and gender-matched controls. Cardiovascular evaluation including heart rate variability (HRV), galvanic skin response (GSR), body fat analysis, and Chalder Fatigue Severity Score was performed on the study participants. The continuous variables of basal anthropometric parameters, GSR values, HRV indices, and body fat parameters are expressed as mean and standard deviation (SD).
Diastolic blood pressure (DBP) was significantly increased among cases ( = 0.04). GSR (average) for cases is higher when compared to controls and was borderline significant ( = 0.05). There were no statistically significant differences in the HRV parameters. Cases showed significantly higher body fat distribution as compared to the control group indicating increased susceptibility of the obese population to COVID-19. Chalder's post-COVID-19 Fatigue Severity Score of cases showed a negative correlation with LF:HF and RMSSD but it was not statistically significant.
In our study, we conclude that there was a significant increase in DBP and GSR (average) with significantly higher visceral fat percentage, body fat percentage, subcutaneous fat percentage, skeletal muscle percentage, and trunk fat percentage in cases as compared to the control group suggestive of higher propensity of obese individuals suffering from COVID-19 and resulting in dysautonomia as compared to the controls.
2019年冠状病毒病（COVID-19）大流行给人类健康造成了沉重损失。本研究的目的是确定印度裔COVID-19康复个体的体脂分布影响、自主神经功能的长期演变及其与查尔德疲劳严重程度评分的相关性。
在生理学系进行了一项病例对照研究，纳入31例病例和29例年龄及性别匹配的对照。对研究参与者进行了心血管评估，包括心率变异性（HRV）、皮肤电反应（GSR）、体脂分析和查尔德疲劳严重程度评分。基础人体测量参数、GSR值、HRV指标和体脂参数的连续变量以均值和标准差（SD）表示。
病例组舒张压（DBP）显著升高（P = 0.04）。病例组的GSR（平均值）高于对照组，差异接近显著（P = 0.05）。HRV参数无统计学显著差异。与对照组相比，病例组的体脂分布显著更高，表明肥胖人群对COVID-19的易感性增加。病例组COVID-19后的查尔德疲劳严重程度评分与低频：高频和RMSSD呈负相关，但无统计学显著性。
在我们的研究中，我们得出结论，与对照组相比，病例组的DBP和GSR（平均值）显著增加，内脏脂肪百分比、体脂百分比、皮下脂肪百分比、骨骼肌百分比和躯干脂肪百分比显著更高，提示肥胖个体患COVID-19的倾向更高，与对照组相比会导致自主神经功能障碍。
