Rinaudo Luca, Cuttone Sofia, Messina Carmelo, Magni Veronica, Capra Davide, Sconfienza Luca Maria, Sardanelli Francesco, Ulivieri Fabio Massimo
Tecnologie Avanzate T.A. srl, Lungo Dora Voghera 36/A, 10153 Torino, Italy.
IRCCS Istituto Ortopedico Galeazzi, 20157 Milano, Italy.
Diagnostics (Basel). 2024 May 18;14(10):1046. doi: 10.3390/diagnostics14101046.
Bone Strain Index (BSI), based on dual-energy X-ray absorptiometry (DXA), is a densitometric index of bone strength of the femur and lumbar spine. Higher BSI values indicate a higher strain applied to bone, predisposing to higher fracture risk. This retrospective, multicentric study on Italian women reports the BSI normative age-specific reference curves. A cohort of Caucasian Italian women aged 20 to 90 years was selected from three different clinical centres. Bone mineral density (BMD) and BSI measurements were obtained for the lumbar spine vertebrae (L1-L4) and for the femur (neck, trochanter and intertrochanter) using Hologic densitometers scans. The data were compared with BMD normative values provided by the densitometer manufacturer. Then, the age-specific BSI curve for the femur and lumbar spine was generated. No significant difference was found between the BMD of the subjects in this study and BMD reference data provided by Hologic ( = 0.68 for femur and = 0.90 for lumbar spine). Spine BSI values (L1-L4) increase by 84% between 20 and 90 years of age. The mean BSI of the total femur increases about 38% in the same age range. The BSI age-specific reference curve could help clinicians improve osteoporosis patient management, allowing an appropriate patient classification according to the bone resistance to the applied loads and fragility fracture risk assessment.
基于双能X线吸收法（DXA）的骨应变指数（BSI）是股骨和腰椎骨强度的密度测量指标。较高的BSI值表明施加于骨骼的应变较高，骨折风险也更高。这项针对意大利女性的回顾性多中心研究报告了按年龄划分的BSI正常参考曲线。从三个不同的临床中心选取了一组年龄在20至90岁之间的意大利白人女性。使用Hologic骨密度仪扫描获取腰椎（L1-L4）和股骨（颈部、大转子和转子间）的骨密度（BMD）和BSI测量值。将这些数据与骨密度仪制造商提供的BMD正常参考值进行比较。然后，生成了股骨和腰椎按年龄划分的BSI曲线。本研究中受试者的BMD与Hologic提供的BMD参考数据之间未发现显著差异（股骨为0.68，腰椎为0.90）。脊柱BSI值（L1-L4）在20至90岁之间增加了84%。在相同年龄范围内，整个股骨的平均BSI增加了约38%。按年龄划分的BSI参考曲线有助于临床医生改善骨质疏松症患者的管理，根据骨骼对施加负荷的抵抗力进行适当的患者分类，并评估脆性骨折风险。
