Saeed Nermin Kamal, Almusawi Safiya, Al-Beltagi Mohammed
Medical Microbiology Section, Department of Pathology, Salmaniya Medical Complex, Governmental Hospitals, Manama 12, Bahrain.
Department of Medical Microbiology, Royal College of Surgeons in Ireland-Bahrain, Busaiteen 15503, Bahrain.
World J Virol. 2024 Dec 25;13(4):98839. doi: 10.5501/wjv.v13.i4.98839.
Invasive fungal infections, particularly candidemia, pose significant clinical challenges globally. Understanding local epidemiology, species distribution, and antifungal susceptibility patterns is crucial for effective management despite regional variations.
To investigate the epidemiology, species distribution, antifungal susceptibility patterns, and associated risk factors of candidemia among patients in Bahrain from 2021 to 2023.
This retrospective study analyzed demographic data, species distribution, antifungal susceptibility profiles, and risk factors among candidemia patients treated at a tertiary care hospital in Bahrain over three years. Data was collected from medical records and analyzed using descriptive statistics.
A total of 430 candidemia cases were identified. The mean age of patients was 65.7 years, with a mortality rate of 85.5%. () was the most common species, followed by , , and emerging multidrug-resistant (). Antifungal susceptibility varied across species, with declining susceptibility to azoles observed, particularly among and . Major risk factors included central venous catheters, broad-spectrum antibiotics, and surgical procedures.
This study highlights the substantial burden of candidemia among older adults in Bahrain, characterized by diverse species. It also concerns levels of antifungal resistance, notably in . The findings underscore the importance of local epidemiological surveillance and tailored treatment strategies to improve outcomes and mitigate the spread of multidrug-resistant species. Future research should focus on molecular resistance mechanisms and optimizing therapeutic approaches to address this growing public health concern.
侵袭性真菌感染，尤其是念珠菌血症，在全球范围内构成了重大的临床挑战。尽管存在地区差异，但了解当地的流行病学、菌种分布和抗真菌药敏模式对于有效管理至关重要。
调查2021年至2023年巴林患者念珠菌血症的流行病学、菌种分布、抗真菌药敏模式及相关危险因素。
这项回顾性研究分析了巴林一家三级护理医院三年内治疗的念珠菌血症患者的人口统计学数据、菌种分布、抗真菌药敏谱和危险因素。数据从病历中收集并使用描述性统计进行分析。
共确定430例念珠菌血症病例。患者的平均年龄为65.7岁，死亡率为85.5%。（此处原文缺失具体菌种名称）是最常见的菌种，其次是（此处原文缺失具体菌种名称）、（此处原文缺失具体菌种名称）和新兴的多重耐药（此处原文缺失具体菌种名称）。不同菌种的抗真菌药敏情况不同，观察到对唑类药物的敏感性下降，尤其是在（此处原文缺失具体菌种名称）和（此处原文缺失具体菌种名称）中。主要危险因素包括中心静脉导管、广谱抗生素和外科手术。
本研究强调了巴林老年人念珠菌血症的沉重负担，其特征是菌种多样。它还涉及抗真菌耐药水平，尤其是在（此处原文缺失具体菌种名称）中。研究结果强调了当地流行病学监测和量身定制治疗策略的重要性，以改善治疗结果并减轻多重耐药（此处原文缺失具体菌种名称）的传播。未来的研究应侧重于分子耐药机制和优化治疗方法，以应对这一日益严重的公共卫生问题。
