Zhang Mengyao, Liu Huiqian, Xu Linlin, Zhang Xizi, Chen Wei, Wang Chengtao
Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Foods. 2024 May 14;13(10):1523. doi: 10.3390/foods13101523.
Histamine, a bioactive component in certain foods such as Huangjiu has been associated with liver injury and disrupted intestinal balance. This study explored the potential therapeutic effects of fucoidan (FCD) in mitigating histamine-induced imbalances in mice. We found that FCD mitigated liver injury, reducing transaminases, oxidative stress, and inflammation. Histological improvements included decreased cell infiltration and necrosis. FCD restored tight junction proteins and suppressed inflammation-related genes. Western blot analysis revealed FCD's impact on TGF-1, -AKT, AKT, CYP2E1, Grp78, NLRP3, Cas-1, and GSDMD. Gut LPS levels decreased with FCD. Gut microbiota analysis showed FCD's modulation effect, reducing Firmicutes and increasing Bacteroides. FCD demonstrates potential in alleviating histamine-induced liver injury, regulating inflammation, and influencing gut microbiota. Further research exploring higher dosages and additional parameters is warranted.
组胺是某些食物（如黄酒）中的一种生物活性成分，与肝损伤和肠道平衡紊乱有关。本研究探讨了岩藻多糖（FCD）在减轻组胺诱导的小鼠体内失衡方面的潜在治疗作用。我们发现FCD减轻了肝损伤，降低了转氨酶、氧化应激和炎症反应。组织学改善包括细胞浸润和坏死减少。FCD恢复了紧密连接蛋白并抑制了炎症相关基因。蛋白质免疫印迹分析揭示了FCD对转化生长因子-1、-AKT、AKT、细胞色素P450 2E1、葡萄糖调节蛋白78、NLRP3、半胱天冬酶-1和Gasdermin D的影响。FCD可降低肠道内脂多糖水平。肠道微生物群分析显示FCD具有调节作用，可减少厚壁菌门并增加拟杆菌门。FCD在减轻组胺诱导的肝损伤、调节炎症和影响肠道微生物群方面显示出潜力。有必要进一步研究探索更高剂量和其他参数。
