Mukherji Aishee B, Idowu Victoria, Zhao Lei, Leung Lawrence L K, Shen Sa, Palaniappan Latha, Morser John
Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.
Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA 94305, USA.
Biomedicines. 2024 Apr 30;12(5):983. doi: 10.3390/biomedicines12050983.
Chemerin acts as both a chemotactic agent and an adipokine that undergoes proteolytic cleavage, converting inactive precursors into their active forms before being subsequently inactivated. Elevated chemerin levels are linked to obesity and type 2 diabetes mellitus (T2D). This study aimed to elucidate the effects of T2D and obesity on chemerin levels by comparing plasma samples from individuals with a normal weight and T2D (BMI < 25; NWD group = 22) with those from individuals who are overweight or obese and have T2D (BMI ≥ 25; OWD group = 39). The total chemerin levels were similar in the NWD and OWD groups, suggesting that T2D may equalize the chemerin levels irrespective of obesity status. The cleavage of chemerin has been previously linked to myocardial infarction and stroke in NWD, with potential implications for inflammation and mortality. OWD plasma exhibited lower levels of cleaved chemerin than the NWD group, suggesting less inflammation in the OWD group. Here, we showed that the interaction between obesity and T2D leads to an equalization in the total chemerin levels. The cleaved chemerin levels and the associated inflammatory state, however, differ significantly, underscoring the complex relationship between chemerin, T2D, and obesity.
chemerin既是一种趋化因子，也是一种脂肪因子，它会经历蛋白水解切割，将无活性前体转化为活性形式，随后再失活。chemerin水平升高与肥胖症和2型糖尿病（T2D）有关。本研究旨在通过比较体重正常且患有T2D的个体（BMI < 25；非超重糖尿病组 = 22）与超重或肥胖且患有T2D的个体（BMI≥25；超重糖尿病组 = 39）的血浆样本，阐明T2D和肥胖症对chemerin水平的影响。非超重糖尿病组和超重糖尿病组的总chemerin水平相似，这表明T2D可能会使chemerin水平趋于均衡，而与肥胖状态无关。先前已发现，在非超重糖尿病个体中，chemerin的切割与心肌梗死和中风有关，对炎症和死亡率可能有影响。超重糖尿病组血浆中chemerin的切割水平低于非超重糖尿病组，表明超重糖尿病组的炎症较轻。在此，我们表明肥胖症与T2D之间的相互作用导致总chemerin水平趋于均衡。然而，chemerin的切割水平及相关炎症状态存在显著差异，这突出了chemerin、T2D和肥胖症之间的复杂关系。
