González-Blanco Carlos, Iglesias-Fortes Sarai, Lockwood Ángela Cristina, Figaredo César, Vitulli Daniela, Guillén Carlos
CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28040 Madrid, Spain.
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, Ciudad Universitaria, 28040 Madrid, Spain.
Biomedicines. 2024 Apr 30;12(5):992. doi: 10.3390/biomedicines12050992.
Extracellular vesicles represent a group of structures with the capacity to communicate with different cells and organs. This complex network of interactions can regulate multiple physiological processes in the organism. Very importantly, these processes can be altered during the appearance of different diseases including cancer, metabolic diseases, etc. In addition, these extracellular vesicles can transport different cargoes, altering the initiation of the disease, driving the progression, or even accelerating the pathogenesis. Then, we have explored the implication of these structures in different alterations such as pancreatic cancer, and in different metabolic alterations such as diabetes and its complications and non-alcoholic fatty liver disease. Finally, we have explored in more detail the communication between the liver and the pancreas. In summary, extracellular vesicles represent a very efficient system for the communication among different tissues and permit an efficient system as biomarkers of the disease, as well as being involved in the extracellular-vesicle-mediated transport of molecules, serving as a potential therapy for different diseases.
细胞外囊泡是一组能够与不同细胞和器官进行通讯的结构。这种复杂的相互作用网络可以调节机体中的多种生理过程。非常重要的是，在包括癌症、代谢性疾病等不同疾病出现时，这些过程会发生改变。此外，这些细胞外囊泡可以运输不同的货物，改变疾病的起始，推动疾病进展，甚至加速发病机制。然后，我们探究了这些结构在不同改变（如胰腺癌）以及不同代谢改变（如糖尿病及其并发症和非酒精性脂肪性肝病）中的作用。最后，我们更详细地探究了肝脏与胰腺之间的通讯。总之，细胞外囊泡是不同组织间非常有效的通讯系统，是一种有效的疾病生物标志物系统，并且参与分子的细胞外囊泡介导运输，可作为不同疾病的潜在治疗手段。
